From SNPedia
rs7442295 is a SNP in the SLC2A9 gene; this gene encodes a glucose transporter.
Based on an initial study of 1900+ hypertensive Caucasian Europeans, the more common allele rs7442295(A) allele was associated with higher serum urate and hyperuracemia (defined as urate >0.4 mMol/l), with a reported odds ratio of 1.89 (CI: 1.36-2.61, p=5 x 10-5). This was also seen in an associated meta-analysis conducted with a broadly representative population and using a surrogate SNP, rs6449213, which is in fairly tight linkage (r2=0.88) with rs7442295.[PMID 18179892]
To put it another way, 79% of white Europeans carry one or two alleles leading to higher serum urate levels. Each copy leads to an average increase of 0.02mMol/l, and, an ~doubling of risk for hyperuracemia.[PMID 18179892]
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| GWAS
|
| SNP
| rs7442295
|
| PubMedID
| [PMID 18179892]
|
| Condition
| Serum urate
|
| Gene
| SLC2A9,WDR1
|
| Risk Allele
| A
|
| pValue
| 2.00E-015
|
| OR
| 0.02
|
| 95% CI
| 0.02-0.03) mMol/L highe
|
| GWAS snp
|
| PMID
| [PMID 18327256]
|
| Trait
| Serum urate
|
| Title
| SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
|
| Risk Allele
| C
|
| P-val
| 3.0000000000000001E-70
|
| Odds Ratio
| 0.35 [NR] mg/dl decrease in uric acid
|
Related to HYPOURICEMIA, RENAL, 2; RHUC2
according to
omim 612076. See
also
Related to SOLUTE CARRIER FAMILY 2 (FACILITATED GLUCOSE TRANSPORTER), MEMBER
according to
omim 606142. See
also
