rs7442295 is a SNP in the SLC2A9 gene; this gene encodes a glucose transporter.
Based on an initial study of 1900+ hypertensive Caucasian Europeans, the more common allele rs7442295(A) allele was associated with higher serum urate and hyperuracemia (defined as urate >0.4 mMol/l), with a reported odds ratio of 1.89 (CI: 1.36-2.61, p=5 x 10-5). This was also seen in an associated meta-analysis conducted with a broadly representative population and using a surrogate SNP, rs6449213, which is in fairly tight linkage (r2=0.88) with rs7442295.[PMID 18179892]
To put it another way, 79% of white Europeans carry one or two alleles leading to higher serum urate levels. Each copy leads to an average increase of 0.02mMol/l, and, an ~doubling of risk for hyperuracemia.[PMID 18179892]
|95% CI||0.02-0.03) mMol/L highe|
|Title||SLC2A9 influences uric acid concentrations with pronounced sex-specific effects|
|Odds Ratio||0.35 [NR] mg/dl decrease in uric acid|
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|qualified_impact||Insufficiently evaluated pathogenic|
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