Rs700651

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rs700651 associated with increased risk of developing intracranial aneurysm.
Orientationplus
Geno Mag Summary
(A;A) 1 Normal risk of aneurysm
(A;G) 1.5 ~1.18x increased risk of aneurysm
(G;G) 2 ~1.56x increased risk of aneurysm
ReferenceGRCh38 38.1/141
Chromosome2
Position197766990
GeneBOLL
is asnp
is mentioned by
dbSNPrs700651
Exacrs700651
PheGenIrs700651
nextbiors700651
hapmaprs700651
1000 genomesrs700651
hgdprs700651
ensemblrs700651
gopubmedrs700651
geneviewrs700651
scholarrs700651
googlers700651
pharmgkbrs700651
gwascentralrs700651
openSNPrs700651
23andMers700651
23andMe allrs700651
SNP Nexus

SNPshotrs700651
SNPdbers700651
MSV3drs700651
GMAF0.3021
Max Magnitude2
? (A;A) (A;G) (G;G) 28
23andMe blog aneurysm
  • rs700651 2 G 1.18x risk 1.56x risk
  • rs10958409 8 A 1.37x risk 1.79x risk
  • rs1333040 9 T 1.29x risk 1.67x risk
GWAS snp
PMID [PMID 18997786OA-icon.png]
Trait Intracranial aneurysm
Title Susceptibility loci for intracranial aneurysm in European and Japanese populations
Risk Allele G
P-val 4E-8
Odds Ratio 1.24 [1.15-1.34]
OMIM612586
DescANEURYSM, INTRACRANIAL BERRY, 9
Variant
Relatedalso



[PMID 20395613] Confirmation of an association of single-nucleotide polymorphism rs1333040 on 9p21 with familial and sporadic intracranial aneurysms in Japanese patients.


GET Evidence
rs700651
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.714286
summary



Increased risk of intracranial (brain aneurysm) with certain SNPs. rs700651(G;G) associated with 1.56x risk of developing an intracranial aneurysm (IA). Heterozygote risk is 1.18x. Other SNPs associated with increased risk of developing IA include rs1333040 and rs10958409.

rs10958409 is located on chromosome 9; rs1333040 is located on chromosome 8; rs700651 is located on chromosome 2.

Unfortunately, the first sign of an intracranial aneurysm is rupture. Catastrophic bleeding and death may result. Specific knowledge of risk may influence screening decision. More information: Intracranial aneurysm screening: indications and advice for practice. [PMID 15664544]. [PMID 22476622] Increased risk of stroke in oral contraceptive users carried replicated genetic variants: a population-based case-control study in China.