From SNPedia
| Genotype | Effect |
|---|
| rs1333040(C;C) | normal |
| rs1333040(C;T) | 1.24x increased myocardial infarction risk, 1.29x increased aneurysm risk |
| rs1333040(T;T) | 1.52x increased myocardial infarction risk, 1.67x increased aneurysm risk |
[
PMID 17478679] A common variant on chromosome 9p21 affects the risk of
myocardial infarction, and is further discussed in this
blog post
spittoon aneurysm
- rs700651 2 G 1.18x risk 1.56x risk
- rs10958409 8 A 1.37x risk 1.79x risk
- rs1333040 9 T 1.29x risk 1.67x risk
| ? | (C;C) (C;T) (T;T) |
|---|
 |
Related to ANEURYSM, INTRACRANIAL BERRY, 6
according to
omim 611892. See
also
| PharmGKB | PA164740744 |
| Name | |
| Annotation | GWAS results: Susceptibility loci for intracranial aneurysm in European and Japanese populations. (Initial Sample Size: 1,580 European cases, 6,276 European controls; Replication Sample Size: 495 Japanese cases, 676 Japanese controls); (Region: 9q21.3; Reported Gene(s): CDKN2A, CDKN2B; Risk Allele: rs1333040-T); (p-value= 0.0000000001).This variant is associated with Intracranial aneurysm. |
| Gene | CDKN2BAS |
| Featue | |
| Evidence | PubMed ID:18997786; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | |
| Curation Level | Non-Curated |
[PMID 19926059] No association of chromosome 9p21.3 variation with clinical and angiographic outcomes after placement of drug-eluting stents
[PMID 20190001] The Relationship Between Smoking and Replicated Sequence Variants on Chromosomes 8 and 9 With Familial Intracranial Aneurysm
