Promethease 0.1.82
Rs4570625
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs4570625 |
| hapmap | rs4570625 |
| hgdp | rs4570625 |
| ensembl | rs4570625 |
| gopubmed | rs4570625 |
| scholar | rs4570625 |
| rs4570625 | |
| pharmgkb | rs4570625 |
| hgvbaseg2p | rs4570625 |
| medrefsnp | rs4570625 |
| 23andMe | rs4570625 |
| SNP Nexus |
| Gene | TPH2 |
| Chromosome | 12 |
| Orientation | plus |
| Position | 70618190 |
| Genotype | Effect |
|---|---|
| rs4570625(G;G) | higher scores on anxiety-related personality traits; greater placebo response |
| rs4570625(G;T) | normal |
| rs4570625(T;T) | normal |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs4570625(G;G) | 1.91.9 | higher scores on anxiety-related personality traits; greater placebo response |
| Rs4570625(G;T) | normal | |
| Rs4570625(T;T) | 00 | normal |
- [PMID 16146581] rs4570625 and rs4565946 linked to the pathogenesis of early-onset obsessive compulsive disorder
- rs4570625 and rs11178997 in TPH2's regulatory region display preferential transmission
- [PMID 19052197] rs4570625(G;G) homozygosity was a significant predictor of clinical placebo response, being associated with greater improvement in anxiety symptoms.
g2b2mh is rs4570625(G;G) is a significant predictor of clinical placebo response? maybe not
[PMID 19132526] panic disorder with a possible gender-dependent effect
| Neighbor | rs11178997 |
| Distance | 230 |
| ? | (G;G) (G;T) (T;T) |
|---|---|
|
| |
Related to ATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD
according to omim 143465. See also
Related to TRYPTOPHAN HYDROXYLASE 2; TPH2
according to omim 607478. See also
[PMID 19894072] A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
[PMID 18427560] Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals
