From SNPedia
| Geno
|
Mag
|
Summary
|
| (G;G)
|
1.9
|
higher scores on anxiety-related personality traits; greater placebo response
|
| (G;T)
|
|
normal
|
| (T;T)
|
0
|
normal
|
| ? | (G;G) (G;T) (T;T) | 28 |
|---|
 |
, also known as G-703T, is a SNP in the tryptophan hydroxylase 2
TPH2 gene. This SNP has been linked to several psychiatric and/or behavioural phenomena, including:
- rs4570625 and rs11178997 in TPH2's regulatory region display preferential transmission
- [PMID 19052197] rs4570625(G;G) homozygosity was a significant predictor of clinical placebo response, being associated with greater improvement in anxiety symptoms.
g2b2mh is rs4570625(G;G) is a significant predictor of clinical placebo response? maybe not
[PMID 19132526] panic disorder with a possible gender-dependent effect
| OMIM | 143465 |
| Desc | ATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD |
| Variant | |
| Related | also |
[PMID 19894072] A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder
[PMID 18427560] Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals
[PMID 20331984] Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumes
[PMID 21396719] Influence of TPH2 variants on diagnosis and response to treatment in patients with major depression, bipolar disorder and schizophrenia
