Rs11178997
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs11178997 |
| hapmap | rs11178997 |
| hgdp | rs11178997 |
| ensembl | rs11178997 |
| gopubmed | rs11178997 |
| scholar | rs11178997 |
| rs11178997 | |
| pharmgkb | rs11178997 |
| hgvbaseg2p | rs11178997 |
| medrefsnp | rs11178997 |
| 23andMe | rs11178997 |
| SNP Nexus |
| Gene | TPH2 |
| Chromosome | 12 |
| Orientation | plus |
| Position | 70618419 |
| Genotype | Effect |
|---|---|
| rs11178997(A;A)* | ? |
| rs11178997(A;T)* | ? |
| rs11178997(T;T) |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs11178997(T;T) | 00 |
paper Association with and bipolar disorder in a Northern Swedish, Isolated Population. 182 patients and 364 unrelated control individuals. P = .001
[PMID 17568567] rs11178997 significantly reduced TPH2 transcriptional activity by 22% and 7% in cell lines might have implications for the development and function of the serotonergic system in the brain.
paper Carriers of the A-Allele of rs11178997 showed a decreased cortisol and ACTH stimulation. might be crucial factors for major depression
pdf paper associated with bipolar disorder
[PMID 17905754] Minor allele yielded odds ratio of 1.5 (CI:1.2-1.9) for increased risk for bipolar disorder in a study of 883 Russian patients.
| Neighbor | rs4570625 |
| Distance | 230 |
[PMID 18427560] Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals
