Rs3803662
| is a | snp |
| is | mentioned by |
| dbSNP | rs3803662 |
| nextbio | rs3803662 |
| hapmap | rs3803662 |
| 1000 genomes | rs3803662 |
| hgdp | rs3803662 |
| ensembl | rs3803662 |
| gopubmed | rs3803662 |
| scholar | rs3803662 |
| rs3803662 | |
| pharmgkb | rs3803662 |
| gwascentral | rs3803662 |
| openSNP | rs3803662 |
| 23andMe | rs3803662 |
| 23andMe all | rs3803662 |
| SNP Nexus | |
| SNPshot | rs3803662 |
| SNPdbe | rs3803662 |
| MSV3d | rs3803662 |
| Gene | LOC643714 |
| Chromosome | 16 |
| Orientation | minus |
| Position | 52586341 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 3 |
| Geno | Mag | Summary |
|---|---|---|
| (C;C) | 0 | normal |
| (C;T) | ? | |
| (T;T) | 3 | 1.6x increased risk for breast cancer |
| ? | (C;C) (C;T) (T;T) | 28 |
|---|---|---|
|
| ||
[PMID 17529974] rs3803662(T;T) have a 1.64-fold greater risk of estrogen receptor-positive tumors
In a study of 1,267 breast cancer patients, rs3803662 heterozygote carriers and minor allele homozygote carriers were more likely to be diagnosed before the age of 60 years (p = 0.025) relative to major allele homozygote carriers.[PMID 17997823]
- rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in TNRC9 (1.14 (1.09-1.21))
[PMID 19005751] rs3803662 confirmed in 988 sporadic breast cancer cases and 1,016 controls from the West of Ireland to be associated with increased risk (odds ratio 1.15, p(allelic) = 5.1 x 10e-2) for breast cancer
| GWAS | |
|---|---|
| SNP | rs3803662 |
| PubMedID | [PMID 17529974] |
| Condition | Breast cancer |
| Gene | TNRC9 |
| Risk Allele | T |
| pValue | 6.00E-019 |
| OR | 1.28 |
| 95% CI | 1.21-1.35 |
| GWAS snp | |
|---|---|
| PMID | [PMID 19330030] |
| Trait | Breast cancer |
| Title | A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1) |
| Risk Allele | T |
| P-val | 1E-9 |
| Odds Ratio | |
| PharmGKB | PA164739881 |
| Name | |
| Annotation | GWAS results: A multistage genome-wide association study in Breast Cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). (Initial Sample Size: 1,145 cases, 1,142 controls; Replication Sample Size: 8,625 cases, 9,657 controls); (Region: 16q12.1; Reported Gene(s): TOX3; Risk Allele: rs3803662-T); (p-value= 0.000000001).This variant is associated with Breast Cancer. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:19330030; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Breast Neoplasms |
| Curation Level | Non-Curated |
[PMID 20406955] Polymorphisms in the TOX3/LOC643714 Locus and Risk of Breast Cancer in African-American Women
| GWAS snp | |
|---|---|
| PMID | [PMID 20453838] |
| Trait | Breast cancer |
| Title | Genome-wide association study identifies five new breast cancer susceptibility loci |
| Risk Allele | A |
| P-val | 3E-15 |
| Odds Ratio | 1.30 [1.22-1.39] |
[PMID 20664043] Incidence of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility loci
[PMID 20054709] Birth weight, breast cancer susceptibility loci, and breast cancer risk
[PMID 20699374] Evaluation of Breast Cancer Susceptibility Loci in Chinese Women
[PMID 20703937] Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: evidence from 62,005 subjects
| GWAS snp | |
|---|---|
| PMID | [PMID 20872241] |
| Trait | |
| Title | A combined analysis of genome-wide association studies in breast cancer |
| Risk Allele | A |
| P-val | 4E-7 |
| Odds Ratio | 1.22 [1.13-1.32] |
| PharmGKB | PA161925624 |
| Name | |
| Annotation | This variant is significantly associated with risk for breast cancer from multiple large scale genome wide association studies. Carriers of the T allele had a 1.64-fold greater risk of estrogen receptor-positive breast cancer and were more likely to be diagnosed before the age of 60 years. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17529967; PubMed ID:17529974; PubMed ID:17997823 |
| Drugs | |
| Diseases | Breast Neoplasms |
| Curation Level | Curated |
| PharmGKB | PA161615667 |
| Name | |
| Annotation | The minor allele of this SNP has been associated with increased risk of breast cancer in BRCA1 and BRCA2 mutation carriers. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:18355772 |
| Drugs | |
| Diseases | Breast Neoplasms |
| Curation Level | Curated |
| PharmGKB | PA162356628 |
| Name | |
| Annotation | GWAS Results: Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer (Initial Sample Size: 1,599 cases, 11,546 controls; Replication Sample Size: 2,934 cases, 5,967 controls; Risk Allele: rs3803662-T). |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17529974; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Breast Neoplasms |
| Curation Level | Non-Curated |
| PharmGKB | PA162356623 |
| Name | |
| Annotation | GWAS Results: Genome-wide association study identifies novel breast cancer susceptibility loci (Initial Sample Size: 390 cases, 364 controls; Replication Sample Size: 26,646 cases, 24,889 controls; Risk Allele: rs3803662-C). |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17529967; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Breast Neoplasms |
| Curation Level | Non-Curated |
[PMID 21197568] Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province
[PMID 21415360] Common genetic variants associated with breast cancer in Korean women and differential susceptibility according to intrinsic subtype
[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
[PMID 21475998] Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United States
[PMID 21748294] Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes
[PMID 21791674] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
[PMID 21795501] Replication of breast cancer GWAS susceptibility loci in the Women's Health Initiative African American SHARe study
[PMID 21996731] Breast cancer genome-wide association studies: there is strength in numbers
[PMID 22452962] A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study
