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rs3803662

From SNPedia

Orientationminus
Stabilizedminus
Geno Mag Summary
(C;C) 0 normal
(C;T)  ?
(T;T) 3 1.6x increased risk for breast cancer
ReferenceGRCh38 38.1/141
Chromosome16
Position52552429
GenePLSCR3
is asnp
is mentioned by
dbSNPrs3803662
ebirs3803662
Exacrs3803662
Maprs3803662
PheGenIrs3803662
hapmaprs3803662
1000 genomesrs3803662
hgdprs3803662
ensemblrs3803662
gopubmedrs3803662
geneviewrs3803662
scholarrs3803662
googlers3803662
pharmgkbrs3803662
gwascentralrs3803662
openSNPrs3803662
23andMers3803662
23andMe allrs3803662
SNP Nexus

SNPshotrs3803662
SNPdbers3803662
MSV3drs3803662
GWAS Ctlgrs3803662
GMAF0.4578
Max Magnitude3
? (C;C) (C;T) (T;T) 28
rs3803662, a SNP associated with the TNRC9 gene, was one of the four strongest associating SNPs found in a genome-wide association study of over 4,000 breast cancer samples.[PMID 17529967OA-icon.png]

[PMID 17529974] rs3803662(T;T) have a 1.64-fold greater risk of estrogen receptor-positive tumors

In a study of 1,267 breast cancer patients, rs3803662 heterozygote carriers and minor allele homozygote carriers were more likely to be diagnosed before the age of 60 years (p = 0.025) relative to major allele homozygote carriers.[PMID 17997823OA-icon.png]

[PMID 18437204OA-icon.png] breast cancer

  • rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in TNRC9 (1.14 (1.09-1.21))

[PMID 19005751] rs3803662 confirmed in 988 sporadic breast cancer cases and 1,016 controls from the West of Ireland to be associated with increased risk (odds ratio 1.15, p(allelic) = 5.1 x 10e-2) for breast cancer

GWAS
SNP rs3803662
PubMedID [PMID 17529974]
Condition Breast cancer
Gene TNRC9
Risk Allele T
pValue 6.00E-019
OR 1.28
95% CI 1.21-1.35


GWAS snp
PMID [PMID 19330030OA-icon.png]
Trait Breast cancer
Title A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
Risk Allele T
P-val 1E-9
Odds Ratio
OMIM114480
DescBREAST CANCER
Variant
Relatedalso
OMIM604370
DescBREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1; BROVCA1
Variant
Relatedalso
OMIM611416
DescTOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 3; TOX3
Variant
Relatedalso
[PMID 20406955OA-icon.png] Polymorphisms in the TOX3/LOC643714 Locus and Risk of Breast Cancer in African-American Women
GWAS snp
PMID [PMID 20453838OA-icon.png]
Trait Breast cancer
Title Genome-wide association study identifies five new breast cancer susceptibility loci
Risk Allele A
P-val 3E-15
Odds Ratio 1.30 [1.22-1.39]

[PMID 20664043] Incidence of breast cancer and its subtypes in relation to individual and multiple low-penetrance genetic susceptibility loci

[PMID 20054709] Birth weight, breast cancer susceptibility loci, and breast cancer risk

[PMID 20699374OA-icon.png] Evaluation of Breast Cancer Susceptibility Loci in Chinese Women

[PMID 20703937] Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: evidence from 62,005 subjects

GWAS snp
PMID [PMID 20872241]
Trait
Title A combined analysis of genome-wide association studies in breast cancer
Risk Allele A
P-val 4E-7
Odds Ratio 1.22 [1.13-1.32]





[PMID 21197568] Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province


[PMID 21415360] Common genetic variants associated with breast cancer in Korean women and differential susceptibility according to intrinsic subtype


[PMID 21445572] Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies


[PMID 21475998OA-icon.png] Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United States


[PMID 21748294] Correlation of breast cancer susceptibility loci with patient characteristics, metastasis-free survival, and mRNA expression of the nearest genes


[PMID 21791674OA-icon.png] Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium


[PMID 21795501OA-icon.png] Replication of breast cancer GWAS susceptibility loci in the Women's Health Initiative African American SHARe study


[PMID 21996731] Breast cancer genome-wide association studies: there is strength in numbers


[PMID 22452962OA-icon.png] A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study


[PMID 18326623OA-icon.png] Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33.


[PMID 18612136OA-icon.png] Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.


[PMID 18681954OA-icon.png] Breast cancer susceptibility loci and mammographic density.


[PMID 18708391OA-icon.png] Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.


[PMID 18772892OA-icon.png] Can genes for mammographic density inform cancer aetiology?


[PMID 18785201OA-icon.png] Novel breast cancer risk alleles and endometrial cancer risk.


[PMID 18973230OA-icon.png] Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.


[PMID 19088016OA-icon.png] Genetic susceptibility loci for breast cancer by estrogen receptor status.


[PMID 19094228OA-icon.png] The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.


[PMID 19219042OA-icon.png] Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.


[PMID 19232126OA-icon.png] Association between breast cancer susceptibility loci and mammographic density: the Multiethnic Cohort.


[PMID 19304784OA-icon.png] Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.


[PMID 19454617OA-icon.png] Genetic variation in the chromosome 17q23 amplicon and breast cancer risk.


[PMID 19567422OA-icon.png] Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.


[PMID 19931039OA-icon.png] Using lifetime risk estimates in personal genomic profiles: estimation of uncertainty.


[PMID 20085711OA-icon.png] Leveraging genetic variability across populations for the identification of causal variants.


[PMID 20146796OA-icon.png] Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.


[PMID 20213080] Genetic variants in trinucleotide repeat-containing 9 (TNRC9) are associated with risk of estrogen receptor positive breast cancer in a Chinese population.


[PMID 20237344OA-icon.png] Performance of common genetic variants in breast-cancer risk models.


[PMID 20484103OA-icon.png] Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.


[PMID 20585626OA-icon.png] Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium.


[PMID 20605201OA-icon.png] Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.


[PMID 21475997] Association between rs3803662 polymorphism of trinucleotide repeat containing 9 gene and breast cancer risk.


[PMID 21596841OA-icon.png] Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.


[PMID 21844186OA-icon.png] Common breast cancer susceptibility loci are associated with triple-negative breast cancer.


[PMID 22045194OA-icon.png] Combined effect of low-penetrant SNPs on breast cancer risk.


[PMID 22160591] A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population.


[PMID 22532573OA-icon.png] The role of genetic breast cancer susceptibility variants as prognostic factors.


GET Evidence
rs3803662
aa_change
aa_change_short
impact pathogenic
qualified_impact Insufficiently evaluated pathogenic
overall_frequency 0.53125
summary



[PMID 23270421OA-icon.png] The risk allele of SNP rs3803662 and the mRNA level of its closest genes TOX3 and LOC643714 predict adverse outcome for breast cancer patients

GWAS snp
PMID [PMID 23001122OA-icon.png]
Trait Breast cancer (male)
Title Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.
Risk Allele
P-val 4E-15
Odds Ratio 1.50 [1.35-1.66]


[PMID 23486537OA-icon.png] Comparison of genetic variation of breast cancer susceptibility genes in Chinese and German populations


[PMID 23717390OA-icon.png] Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm


[PMID 24289300OA-icon.png] Effects of lifestyle and single nucleotide polymorphisms on breast cancer risk: a case--control study in Japanese women

GWAS snp
PMID [PMID 23535733OA-icon.png]
Trait Breast cancer
Title Genome-wide association studies identify four ER negative-specific breast cancer risk loci.
Risk Allele T
P-val 6E-13
Odds Ratio 1.14 [1.10-1.18]
GWAS snp
PMID [PMID 23535729OA-icon.png]
Trait Breast cancer
Title Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
Risk Allele A
P-val 2E-114
Odds Ratio 1.24 [1.21-1.27]


[PMID 22910930OA-icon.png] Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians.


[PMID 23577780OA-icon.png] Associations between single-nucleotide polymorphisms and epidural ropivacaine consumption in patients undergoing breast cancer surgery.

GWAS snp
PMID [PMID 24143190OA-icon.png]
Trait Breast cancer
Title Genome-wide association study of breast cancer in the Japanese population.
Risk Allele T
P-val 3E-11
Odds Ratio 1.21 [1.146-1.284]


[PMID 25139936OA-icon.png] Association of Cancer Susceptibility Variants with Risk of Multiple Primary Cancers: the Population Architecture using Genomics and Epidemiology Study


[PMID 24532140] Association of genetic variants at TOX3, 2q35 and 8q24 with the risk of familial and early-onset breast cancer in a South-American population


[PMID 25784121] Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography


[PMID 25881232OA-icon.png] Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography


[PMID 26070784OA-icon.png] Genetic risk variants associated with in situ breast cancer


[PMID 26711978] [Associations between TOX3 rs3803662 polymorphisms and immunological markers of breast cancer].


[PMID 26911390] TNRC9 rs12443621 and FGFR2 rs2981582 polymorphisms and breast cancer risk.


[PMID 27572905] Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women.