|(A;C)||1.1||Very slightly higher risk for breast cancer|
|(C;C)||1.1||Very slightly higher risk for breast cancer|
rs889312 was one of the four strongest associating SNPs found in a genome-wide association study of over 4,000 breast cancer samples. [PMID 17529967]. From a DeCode user report, it appears that the risk allele is C; this A;A individual reportedly has 0.93x risk of breast cancer. [PMID 17529967]
In a study of 1,267 breast cancer patients, rs889312 heterozygotes and minor allele homozygotes were less likely to be lymph node positive at breast cancer diagnosis (P = 0.044) relative to major allele homozygote carriers. [PMID 17997823]
A meta-analysis including 26,015 cases and 33,962 controls concludes that the rs889312(C) allele is clearly a significant - but quite weak - contributor to increased risk for breast cancer.[PMID 20809358]
- rs2981582, rs3803662, and rs889312) showed weak but significant associations with ER-negative disease, the strongest association being for rs3803662 in TNRC9 (1.14 (1.09-1.21))
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|Odds Ratio||1.22 [1.14-1.30]|
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|qualified_impact||Insufficiently evaluated pathogenic|
[PMID 23225170] Genetic variants in FGFR2 and MAP3K1 are associated with the risk of familial and early-onset breast cancer in a South-American population
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|Odds Ratio||1.12 [1.10-1.15]|
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|Trait||Breast cancer (early onset)|
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|Odds Ratio||1.29 [NR]|
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