Rs2981582

From SNPedia

rs2981582, a SNP associated with the FGFR2 gene, was one of the four strongest associating SNPs found in a genome-wide association study of over 4,000 breast cancer samples.[PMID 17529967]

[PMID 18437204] breast cancer

• rs2981582 in FGFR2 was more strongly related to ER-positive (per-allele odds ratio 1.31 (CI: 1.27-1.36)) than ER-negative (odds ratio 1.08 (CI:1.03-1.14)) disease (p for heterogeneity = 10(-13)).

[PMID 18579814] breast cancer

• rs2981582, while on it's own still of fairly small effect, was the most significant (other than from family history and/or BRCA1 or BRCA2 testing) of the SNPs chosen in a 7 SNP panel to help estimate risk of breast cancer

[PMID 18845558] breast cancer

• Based on a study of 1,049 Chinese breast cancer patients, carriers of risk alleles at three SNPs (rs2981582, rs1219648 and rs2420946) were at 1.36x increased risk for breast cancer (CI: 1.13-1.62, p = 0.001).

[PMID 18973230] A study of 1,173 Caucasian ovarian cancer patients did not find strong support for an association with rs2981582.

[PMID 19005751] rs2981582 confirmed in 988 sporadic breast cancer cases and 1,016 controls from the West of Ireland to be associated with increased risk (odds ratio 1.22, p(allelic) = 2.2 x 10e-3) for breast cancer

[PMID 19028704] A study of 1,225 Caucasian breast cancer patients found a significant association between rs2981582 but only in women with estrogen receptor positive (ER+), progesterone receptor positive (PR+) and HER2/Neu negative (HER2-) tumors.

GWAS
SNP	rs2981582
PubMedID	[PMID 17529967]
Condition	Breast cancer
Gene	FGFR2
Risk Allele	G
pValue	2.00E-076
OR	1.26
95% CI	1.23-1.30

[PMID 19536173] Association of FGFR2 gene polymorphisms with the risk of breast cancer in population of West Siberia