Know any genomes at Twitter support? Contact us if you can help get their attention.
Rs3135506 (also known as S19W) is associated with severe hypertriglyceridemia. 132 patients of European ancestry with severe HTG (fasting plasma TG>10 mmol/L), and 351 matched normolipidemic controls. PMID 19629056] Apolipoprotein A5 and Lipoprotein Lipase Interact to Modulate Anthropometric Measures in Hispanics of Caribbean Origin
[PMID 20395964] Different effects of apolipoprotein A5 SNPs and haplotypes on triglyceride concentration in three ethnic origins
[PMID 20429872] Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study
[PMID 20883102] Haplotype analysis of the apolipoprotein A5 gene in obese pediatric patients
[PMID 22425169] Vitamin D dependent effects of APOA5 polymorphisms on HDL cholesterol.
|CLNDBN||Hypertriglyceridemia, susceptibility to|
|CLNSRC||OMIM Allelic Variant|
[PMID 17357083] Medical sequencing at the extremes of human body mass.
[PMID 17903299] A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.
[PMID 18441017] An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.
[PMID 18596051] Polygenic determinants of severe hypertriglyceridemia.
[PMID 18660489] Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.
[PMID 18789138] The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides.
[PMID 18801202] Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease.
[PMID 18974842] Gender differences in genetic risk profiles for cardiovascular disease.
[PMID 19018513] The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.
[PMID 19041386] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
[PMID 19056598] Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.
[PMID 19057464] Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study.
[PMID 19148283] Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.
[PMID 19185284] Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
[PMID 19435741] Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
[PMID 19787382] Introduction to the DISRUPT postprandial database: subjects, studies and methodologies.
[PMID 19878569] Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.
[PMID 19910639] Genetic association and interaction analysis of USF1 and APOA5 on lipid levels and atherosclerosis.
[PMID 20406163] Fenofibrate and metabolic syndrome.
[PMID 21671989] Dosing equation for tacrolimus using genetic variants and clinical factors.
|qualified_impact||Low clinical importance, Likely pathogenic|
|summary||This variant, also known as APOA5*3, is associated with higher plasma triglyceride concentrations but no significant correlation with coronary artery disease itself has been found.|
[PMID 23065249] Apolipoprotein A5 polymorphisms in Turkish population: association with serum lipid profile and risk of ischemic stroke.