APOA5
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | apolipoprotein A-V |
| EntrezGene | 116519 |
| PheGenI | 116519 |
| VariationViewer | 116519 |
| ClinVar | APOA5 |
| GeneCards | APOA5 |
| dbSNP | 116519 |
| Diseases | APOA5 |
| SADR | 116519 |
| HugeNav | 116519 |
| wikipedia | APOA5 |
| APOA5 | |
| gopubmed | APOA5 |
| EVS | APOA5 |
| HEFalMp | APOA5 |
| MyGene2 | APOA5 |
| 23andMe | APOA5 |
| UniProt | Q6Q788 |
| Ensembl | ENSG00000110243 |
| OMIM | 606368 |
| # SNPs | 14 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs10750097 | 0 | 116,793,324 | |
| rs121917821 | 0 | 116,790,814 | |
| rs147528707 | 0 | 116,790,292 | |
| rs201079485 | 0 | 116,790,940 | |
| rs2072560 | 0 | 116,791,110 | |
| rs2075291 | 0 | 116,790,676 | |
| rs2266788 | 0 | 116,789,970 | |
| rs28939090 | 0 | 116,791,691 | |
| rs3135506 | 0 | 116,791,691 | |
| rs34089864 | 0 | 116,790,052 | |
| rs619054 | 0 | 116,790,097 | |
| rs651821 | 0 | 116,791,863 | |
| rs662799 | 2 | 116,792,991 | |
| rs72525532 | 0 | 116,789,842 |
SNPs in the apolipoprotein A-V gene, APOA5, have primarily been associated with plasma lipoprotein levels and associated downstream consequences, such as weight gain and heart disease risk.
Significant SNPs of APOA5 include:
- rs2075291: Associated with high triglyceride levels in Asians.
- rs3135506, also known as S19W, is associated with hypertriglyceridemia. [PMID 18596051]
- rs662799 :
- [PMID 16682041] 13% of the population have rs662799 -1131T>C which prevents weight gain from high fat diets.
- [PMID 17211608] rs662799 -1131T>C in APOA5 is present in approximately 13% of this population, modulates the effect of fat intake on BMI and obesity risk in both men and women.
- Misc. (awaiting categorization):
- dbsnp
- S19W is also known as rs3135506
- [PMID 16943456]
- [PMID 16957409] 2 SNPs
- [PMID 16474174] Variants in the gene APOA5 are associated with carotid atherosclerosis, and modification by obesity: the Framingham Study.
