rs662799 is a SNP in the APOA5 gene. The rarer rs662799(C) allele has been associated in multiple reports (cited below) to be associated with higher triglyceride levels.
Independently of triglyceride levels, perhaps, a study based on 1,864 Italian patients <45 years old at the time of their first heart attack (myocardial infarction) concluded that this SNP is associated with higher risk for an early heart attack, with a per C allele odds ratio of 1.44 (CI: 1.23-1.69, p = 6.7 × 10(-5)).[PMID 21130994]
This SNP has also been reported to help prevent weight gain from high fat diets.
[PMID 17211608] 1,073 men and 1,207 women participating in the Framingham Offspring Study rs662799 -1131T>C in modulates the effect of fat intake on BMI and obesity risk in both men and women. Individuals with at least one C allele gained significantly less weight on a high fat diet than those homozygous for the T allele.
[PMID 19732897] Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese
[PMID 20395964] Different effects of apolipoprotein A5 SNPs and haplotypes on triglyceride concentration in three ethnic origins
[PMID 20429872] Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study
[PMID 20571505] A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese
[PMID 20883102] Haplotype analysis of the apolipoprotein A5 gene in obese pediatric patients
[PMID 21130994] Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction
[PMID 21375366] Impact of apolipoprotein A5 (APOA5) polymorphisms on serum triglyceride levels in schizophrenic patients under long-term atypical antipsychotic treatment
[PMID 16670016] Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV gene.
[PMID 17357073] Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.
[PMID 17903299] A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.
[PMID 18078817] Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics.
[PMID 18196181] Correction of population stratification in large multi-ethnic association studies.
[PMID 18441017] An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.
[PMID 18789138] The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides.
[PMID 19018513] The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.
[PMID 19041386] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.
[PMID 19056598] Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.
[PMID 19057464] Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study.
[PMID 19148283] Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.
[PMID 19185284] Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.
[PMID 19299407] Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.
[PMID 19435741] Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.
[PMID 19656773] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.
[PMID 19787382] Introduction to the DISRUPT postprandial database: subjects, studies and methodologies.
[PMID 20406163] Fenofibrate and metabolic syndrome.
[PMID 20452521] Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.
[PMID 20570915] Genetic determinants of major blood lipids in Pakistanis compared with Europeans.
[PMID 20832063] Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study.
[PMID 21054477] Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese.
[PMID 21324458] Association of gene variants with lipid levels in response to fenofibrate is influenced by metabolic syndrome status.
[PMID 21423763] Interactions of the apolipoprotein A5 gene polymorphisms and alcohol consumption on serum lipid levels.
[PMID 21438666] Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes.
[PMID 22387725] Rapid genotyping of APOA5 -1131T>C polymorphism using high resolution melting analysis with unlabeled probes.
|qualified_impact||Insufficiently evaluated pharmacogenetic|
|summary||associated with the triglyceride levels and the risk of first heart attack|
[PMID 23150898] Evaluation of seven common lipid associated loci in a large Indian sib pair study
[PMID 23050023] Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals
[PMID 22517333] Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study.
[PMID 22576629] Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome.
[PMID 22924697] Interactions between the apolipoprotein a1/c3/a5 haplotypes and alcohol consumption on serum lipid levels.
[PMID 23065249] Apolipoprotein A5 polymorphisms in Turkish population: association with serum lipid profile and risk of ischemic stroke.
[PMID 23459084] Central obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster.
[PMID 24402875] Genetic association of lipid metabolism related SNPs with myocardial infarction in the Pakistani population
|Title||Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.|
|Odds Ratio||.14 [0.12-0.16] unit decrease|
[PMID 24462044] The association between APOA5 haplotypes and plasma lipids is not modified by energy or fat intake: the Czech HAPIEE study