Rs662799

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Orientationplus
Geno Mag Summary
(A;A) 0 normal
(A;G) 2 1.4x higher early heart attack risk; less weight gain on high fat diets
(G;G) 2 2x higher early heart attack risk; less weight gain on high fat diets
ReferenceGRCh38 38.1/141
Chromosome11
Position116792991
GeneAPOA5
is asnp
is mentioned by
dbSNPrs662799
Exacrs662799
PheGenIrs662799
nextbiors662799
hapmaprs662799
1000 genomesrs662799
hgdprs662799
ensemblrs662799
gopubmedrs662799
geneviewrs662799
scholarrs662799
googlers662799
pharmgkbrs662799
gwascentralrs662799
openSNPrs662799
23andMers662799
23andMe allrs662799
SNP Nexus

SNPshotrs662799
SNPdbers662799
MSV3drs662799
GMAF0.1524
Max Magnitude2
? (A;A) (A;G) (G;G) 28
rs662799 is a SNP in the APOA5 gene. The rarer rs662799(C) allele has been associated in multiple reports (cited below) to be associated with higher triglyceride levels.

Independently of triglyceride levels, perhaps, a study based on 1,864 Italian patients <45 years old at the time of their first heart attack (myocardial infarction) concluded that this SNP is associated with higher risk for an early heart attack, with a per C allele odds ratio of 1.44 (CI: 1.23-1.69, p = 6.7 × 10(-5)).[PMID 21130994]

This SNP has also been reported to help prevent weight gain from high fat diets.

[PMID 17211608] 1,073 men and 1,207 women participating in the Framingham Offspring Study rs662799 -1131T>C in modulates the effect of fat intake on BMI and obesity risk in both men and women. Individuals with at least one C allele gained significantly less weight on a high fat diet than those homozygous for the T allele.

[PMID 18596051] rs662799 (-1131T>C) influences severe hypertriglyceridemia. 132 patients of European ancestry with severe HTG (fasting plasma TG>10 mmol/L), and 351 matched controls


[PMID 19732897] Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese


[PMID 20395964] Different effects of apolipoprotein A5 SNPs and haplotypes on triglyceride concentration in three ethnic origins

[PMID 20429872OA-icon.png] Additive effects of LPL, APOA5 and APOE variant combinations on triglyceride levels and hypertriglyceridemia: results of the ICARIA genetic sub-study

[PMID 20571505OA-icon.png] A single nucleotide polymorphism in APOA5 determines triglyceride levels in Hong Kong and Guangzhou Chinese

[PMID 20883102] Haplotype analysis of the apolipoprotein A5 gene in obese pediatric patients


[PMID 21130994] Strong association of the APOA5-1131T>C gene variant and early-onset acute myocardial infarction


[PMID 21375366] Impact of apolipoprotein A5 (APOA5) polymorphisms on serum triglyceride levels in schizophrenic patients under long-term atypical antipsychotic treatment


[PMID 16670016OA-icon.png] Allelic drop-out may occur with a primer binding site polymorphism for the commonly used RFLP assay for the -1131T>C polymorphism of the Apolipoprotein AV gene.


[PMID 17357073OA-icon.png] Genetic analysis of 103 candidate genes for coronary artery disease and associated phenotypes in a founder population reveals a new association between endothelin-1 and high-density lipoprotein cholesterol.


[PMID 17903299OA-icon.png] A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.


[PMID 18078817OA-icon.png] Multiple genetic determinants of plasma lipid levels in Caribbean Hispanics.


[PMID 18196181OA-icon.png] Correction of population stratification in large multi-ethnic association studies.


[PMID 18441017OA-icon.png] An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients.


[PMID 18789138OA-icon.png] The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides.


[PMID 19018513] The association of common genetic variants in the APOA5, LPL and GCK genes with longitudinal changes in metabolic and cardiovascular traits.


[PMID 19041386OA-icon.png] Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.


[PMID 19056598OA-icon.png] Association between glucokinase regulatory protein (GCKR) and apolipoprotein A5 (APOA5) gene polymorphisms and triacylglycerol concentrations in fasting, postprandial, and fenofibrate-treated states.


[PMID 19057464OA-icon.png] Pharmacogenetic association of the APOA1/C3/A4/A5 gene cluster and lipid responses to fenofibrate: the genetics of lipid-lowering drugs and diet network study.


[PMID 19148283OA-icon.png] Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.


[PMID 19185284OA-icon.png] Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.


[PMID 19299407OA-icon.png] Replication of genetic associations with plasma lipoprotein traits in a multiethnic sample.


[PMID 19435741OA-icon.png] Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.


[PMID 19656773OA-icon.png] A polygenic basis for four classical Fredrickson hyperlipoproteinemia phenotypes that are characterized by hypertriglyceridemia.


[PMID 19787382OA-icon.png] Introduction to the DISRUPT postprandial database: subjects, studies and methodologies.


[PMID 20406163] Fenofibrate and metabolic syndrome.


[PMID 20452521OA-icon.png] Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies.


[PMID 20570915] Genetic determinants of major blood lipids in Pakistanis compared with Europeans.


[PMID 20832063] Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study.


[PMID 21054477] Association of a genetic variant in the apolipoprotein A5 gene with the metabolic syndrome in Chinese.


[PMID 21324458OA-icon.png] Association of gene variants with lipid levels in response to fenofibrate is influenced by metabolic syndrome status.


[PMID 21423763OA-icon.png] Interactions of the apolipoprotein A5 gene polymorphisms and alcohol consumption on serum lipid levels.


[PMID 21438666] Association of PON1 and APOA5 gene polymorphisms in a cohort of Indian patients having coronary artery disease with and without type 2 diabetes.


[PMID 22387725] Rapid genotyping of APOA5 -1131T>C polymorphism using high resolution melting analysis with unlabeled probes.


GET Evidence
rs662799
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.898438
summary associated with the triglyceride levels and the risk of first heart attack



[PMID 23150898OA-icon.png] Evaluation of seven common lipid associated loci in a large Indian sib pair study

Response to Diet and Exercise


[PMID 23050023OA-icon.png] Association of genetic variants influencing lipid levels with coronary artery disease in Japanese individuals


[PMID 22517333] Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study.


[PMID 22576629] Synergistic effects of genetic variants of APOA5 and BTN2A1 on dyslipidemia or metabolic syndrome.


[PMID 22924697] Interactions between the apolipoprotein a1/c3/a5 haplotypes and alcohol consumption on serum lipid levels.


[PMID 23065249] Apolipoprotein A5 polymorphisms in Turkish population: association with serum lipid profile and risk of ischemic stroke.


[PMID 23459084OA-icon.png] Central obesity in males affected by a dyslipidemia-associated genetic polymorphism on APOA1/C3/A4/A5 gene cluster.


[PMID 24402875] Genetic association of lipid metabolism related SNPs with myocardial infarction in the Pakistani population

GWAS snp
PMID [PMID 24023260]
Trait Lipid traits
Title Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.
Risk Allele A
P-val 6E-24
Odds Ratio .14 [0.12-0.16] unit decrease


[PMID 24462044] The association between APOA5 haplotypes and plasma lipids is not modified by energy or fat intake: the Czech HAPIEE study