From SNPedia
| Associated with increased susceptibility to alcohol withdrawal symptoms and ADHD. |
, a SNP in the dopamine transporter
SLC6A3 gene, has been associated with more severe symptoms upon alcohol withdrawal, such as seizures, in a study of 250 Caucasian alcohol-dependent patients. Two haplotypes appear to be tagged by this SNP and a neighbor,
rs27048. The rs27072 polymorphism has been shown to be significantly associated with ADHD in clinical samples of Canadian children aged 6 to 16 [Feng et al., 2005] and the significant association was also reported by Ouellet-Morin et al. in a Canadian twin study, 2008 (Am. J. of Medical Genetics Part B, 147B:1442-1449 (2008). [
PMID 18070248]
| ? | (C;C) (C;T) (T;T) |
|---|
 |
Related to ATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD
according to
omim 143465. See
also
Related to SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER, DOPAMINE),
according to
omim 126455. See
also
[PMID 19740369] The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds
[PMID 19879111] Association of promoter variants of human dopamine transporter gene with schizophrenia in Han Chinese
