From SNPedia
| Associated with increased susceptibility to alcohol withdrawal symptoms and ADHD. |
| Geno
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Mag
|
Summary
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| (C;C)
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2
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2x risk of severe alcohol withdrawal
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| (C;T)
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0
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normal
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| (T;T)
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0
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normal
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| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
, a SNP in the dopamine transporter
SLC6A3 gene, has been associated with more severe symptoms upon alcohol withdrawal, such as seizures, in a study of 250 Caucasian alcohol-dependent patients. Two haplotypes appear to be tagged by this SNP and a neighbor,
rs27048. The rs27072 polymorphism has been shown to be significantly associated with
ADHD in clinical samples of Canadian children aged 6 to 16 [Feng et al., 2005] and the significant association was also reported by Ouellet-Morin et al. in a Canadian twin study, 2008 (Am. J. of Medical Genetics Part B, 147B:1442-1449 (2008). [
PMID 18070248]
| OMIM | 143465 |
| Desc | ATTENTION DEFICIT-HYPERACTIVITY DISORDER; ADHD |
| Variant | |
| Related | also |
| OMIM | 126455 |
| Desc | SOLUTE CARRIER FAMILY 6 (NEUROTRANSMITTER TRANSPORTER, DOPAMINE), |
| Variant | |
| Related | also |
[PMID 19740369]The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds.
[PMID 19879111]Association of promoter variants of human dopamine transporter gene with schizophrenia in Han Chinese.
[PMID 21525861]Dopamine Transporter Gene Variant Affecting Expression in Human Brain is Associated with Bipolar Disorder.
[PMID 16082693]Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD).
[PMID 18165969]Association of the dopamine transporter gene and ADHD symptoms in a Canadian population-based sample of same-age twins.
[PMID 19506906]Candidate gene studies of ADHD: a meta-analytic review.
