From SNPedia
| Geno
|
Mag
|
Summary
|
| (A;A)
|
2
|
|
| (C;C)
|
|
1.5x risk for Crohn's disease
|
| (C;T)
|
|
1.5x risk for Crohn's disease; 2x risk for Graves' disease
|
| (T;T)
|
|
2.4x risk for Graves' disease
|
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
SNP
rs2201841, in the
IL23R gene, is associated with increased risk for
Crohn's disease in both Jewish and non-Jewish populations. [
PMID 17068223]
Another study found that the "A allele" and "AA genotype" were significantly overrepresented in Graves' disease patients with Graves ophthalmopathy, based on 216 North American patients. The odds ratios reported were 2.04 for the allele (p=1x10-4), and for the so-called "AA" genotype (presumably rs2201841(T;T) when correctly oriented to the dbSNP orientation), 2.4 (p=1x10-4).[PMID 18073300]
spittoon psoriasis
Europeans
| GWAS snp
|
| PMID
|
[PMID 19169254]
|
| Trait
|
Psoriasis
|
| Title
|
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
|
| Risk Allele
|
G
|
| P-val
|
3E-8
|
| Odds Ratio
|
1.13 None
|
[PMID 19034457] Lack of association between interleukin 23 receptor gene polymorphisms and rheumatoid arthritis susceptibility
| PharmGKB | PA164740040 |
| Name | |
| Annotation | GWAS results: Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. (Initial Sample Size: 1,359 cases, 1,400 controls; Replication Sample Size: 5,048 cases, 5,041 controls); (Region: 1p31.3; Reported Gene(s): IL23R; Risk Allele: rs2201841-G); (p-value= 0.00000003).This variant is associated with Psoriasis. |
| Gene | IL23R |
| Featue | |
| Evidence | PubMed ID:19169254; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Psoriasis |
| Curation Level | Non-Curated |
| PharmGKB | PA162356491 |
| Name | |
| Annotation | GWAS results: Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci (Initial Sample Size: 382 trios; Replication Sample Size: 521 trios, 750 cases, 828 controls). This variant is associated with Crohn's disease. This variant is associated with Crohn's disease. |
| Gene | IL23R |
| Featue | |
| Evidence | PubMed ID:17804789; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Crohn Disease |
| Curation Level | Non-Curated |
[PMID 22089529] Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
[PMID 22440928] Perianal Crohn's Disease: Predictive Factors and Genotype-Phenotype Correlations
[PMID 22411504] Contribution of higher risk genes and European admixture to Crohn's disease in African Americans.
