Psoriasis

From SNPedia

Psoriasis is a disease which causes red scaly patches to appear on the skin.

rs1265181(G) or the equivalent and non ambiguous rs1265159(A) increases risk by 22x and marks the HLA-Cw*0602 allele.

Numerous other SNPs have been linked to psoriasis, few have been unequivocally associated with it, with the exception of a major susceptibility locus on chromosome 6 that appears to be the HLA-Cw*0602 allele.[PMID 18021893] SNPs associated with the Class I region include:

• rs10484554, which lies 34.7 kb upstream of HLA-C
• rs2395029, encoding the G2V variant within the Class I HCP5 gene

spittoon psoriasis Europeans

• rs20541(G) 1.27
• rs610604(G) 1.19
• rs2066808(A) 1.34
• rs2201841(G) 1.13
• rs4112788(G) 1.41

Chinese

• rs1265159(A) 22.62 Proxy SNP for rs1265181
• rs3213094(C) 1.28
• rs4085613(G) 1.32

SNPs that have been reported other than these include:

• rs887466
• rs4379333
• rs734232
• The ACE gene I/D SNPs; see rs4340 for example
• rs11209026, in the IL23R gene
• rs6887695, in the IL12B gene
• rs7993214, on ch 13q13
• rs6701216
• rs3803369, on ch 15q21