From SNPedia
rs1954787, located in an intron of the GRIK4 gene, was found to be associated with a somewhat increased rate of successful response to treatment of depression with the drug citalopram. [PMID 17671280]
From the abstract of this article:
"The effect size of (this) GRIK4 marker alone was modest, but homozygote carriers of the treatment-response-associated marker alleles of both the GRIK4 and HTR2A (see rs7997012) genes were 23% less likely to experience nonresponse to (citalopram) treatment relative to participants who did not carry any of these marker alleles."
| ? | (C;C) (C;T) (T;T) |
|---|
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[PMID 19924111] Polymorphisms in GRIK4, HTR2A, and FKBP5 Show Interactive Effects in Predicting Remission to Antidepressant Treatment
| PharmGKB | PA162316593 |
| Name | |
| Annotation | A study in 1,816 eligible patients from the STAR*D cohort found that genetic variation in a kainic acid-type glutamate receptor is reproducibly associated with response to the antidepressant citalopram. |
| Gene | GRIK4 |
| Featue | |
| Evidence | PubMed ID:17671280 |
| Drugs | citalopram |
| Diseases | Depression |
| Curation Level | Curated |
