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The GRIK4 gene encodes a member (KA1) of the kainate-type ionotropic glutamate receptor family.
One study identified two discrete regions of disease risk within the GRIK4 locus in a Caucasian population: three SNPs and one associated haplotype indicating increased risk for schizophrenia (p=0.0005, odds ratio 1.45, CI: 1.182-1.787) and two SNPs and a haplotype associated with a protective effect against bipolar disorder (p=0.0002, odds ratio of 0.624, CI: 0.485-0.802). However, after permutation analysis to correct for multiple testing, the independent SNPs were no longer significant, and only the schizophrenia and bipolar disorder haplotypes remained significant.[PMID 16819533]