Rs7997012
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs7997012 |
| hapmap | rs7997012 |
| hgdp | rs7997012 |
| ensembl | rs7997012 |
| gopubmed | rs7997012 |
| scholar | rs7997012 |
| rs7997012 | |
| pharmgkb | rs7997012 |
| hgvbaseg2p | rs7997012 |
| medrefsnp | rs7997012 |
| 23andMe | rs7997012 |
| SNP Nexus |
| Gene | HTR2A |
| Chromosome | 13 |
| Orientation | plus |
| Position | 46309985 |
| Genotype | Effect |
|---|---|
| rs7997012(A;A) | ~18% more likely to respond to citalopram |
| rs7997012(A;G) | normal risk |
| rs7997012(G;G) | ~18% less likely to respond to citalopram |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs7997012(A;A) | ~18% more likely to respond to citalopram | |
| Rs7997012(A;G) | 00 | normal risk |
| Rs7997012(G;G) | ~18% less likely to respond to citalopram |
rs7997012, located in an intron of the HTR2A gene, was found to be associated with a somewhat increased rate of successful response to treatment of depression with the drug citalopram. [PMID 16642436]
From this article [PMID 16642436]:
"HTR2A encodes the serotonin 2A receptor, which is downregulated by citalopram. Participants who were homozygous for the A allele had an 18% reduction in absolute risk of having no response to treatment, compared with those homozygous for the other allele."
- See also Anxiety Blog posting
| ? | (A;A) (A;G) (G;G) |
|---|---|
|
| |
[PMID 19095219] Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder
[PMID 19428704] Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population
[PMID 19590397] 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression
[PMID 19924111] Polymorphisms in GRIK4, HTR2A, and FKBP5 Show Interactive Effects in Predicting Remission to Antidepressant Treatment
| PharmGKB | PA161614203 |
| Name | |
| Annotation | In one study, subjects homozygous for allele A had a reduction in absolute risk of having no response to treatment with citalopram for major depressive disorder. The allele was found to be more frequent in white than in black subjects, and this is consistant with racial differences in response to antidepressant treatment. |
| Gene | HTR2A |
| Featue | |
| Evidence | PubMed ID:16642436 |
| Drugs | citalopram |
| Diseases | Depressive Disorder, Major |
| Curation Level | Curated |
[PMID 19758789] HTR2A gene variation is involved in antidepressant treatment response
