|(A;A)||~18% more likely to respond to citalopram|
|(G;G)||~18% less likely to respond to citalopram|
From this article [PMID 16642436]:
"HTR2A encodes the serotonin 2A receptor, which is downregulated by citalopram. Participants who were homozygous for the A allele had an 18% reduction in absolute risk of having no response to treatment, compared with those homozygous for the other allele."
- See also Anxiety Blog posting
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[PMID 18803430] Pharmacogenetics of major depression: insights from level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial.
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|qualified_impact||Insufficiently evaluated pharmacogenetic|
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[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.
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