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Rs7997012

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Orientationplus
is asnp
is mentioned by
dbSNPrs7997012
PheGenIrs7997012
nextbiors7997012
hapmaprs7997012
1000 genomesrs7997012
hgdprs7997012
ensemblrs7997012
gopubmedrs7997012
geneviewrs7997012
scholarrs7997012
googlers7997012
pharmgkbrs7997012
gwascentralrs7997012
openSNPrs7997012
23andMers7997012
23andMe allrs7997012
SNP Nexus

SNPshotrs7997012
SNPdbers7997012
MSV3drs7997012
GeneHTR2A
Chromosome13
Orientationplus
GMAF0.2741
Position46837850
ReferenceGRCh38 38.1/141
Max Magnitude0
Geno Mag Summary
(A;A) ~18% more likely to respond to citalopram
(A;G) 0 normal risk
(G;G) ~18% less likely to respond to citalopram
? (A;A) (A;G) (G;G) 28
rs7997012, located in an intron of the HTR2A gene, was found to be associated with a somewhat increased rate of successful response to treatment of depression with the drug citalopram. [PMID 16642436OA-icon.png]

From this article [PMID 16642436OA-icon.png]:

"HTR2A encodes the serotonin 2A receptor, which is downregulated by citalopram. Participants who were homozygous for the A allele had an 18% reduction in absolute risk of having no response to treatment, compared with those homozygous for the other allele."


[PMID 19095219] Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder

OMIM182135
Desc5-@HYDROXYTRYPTAMINE RECEPTOR 2A; HTR2A
Variant
Relatedalso

[PMID 19428704] Genetic association analysis of serotonin 2A receptor gene (HTR2A) with bipolar disorder and major depressive disorder in the Japanese population

[PMID 19590397] 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression

[PMID 19924111OA-icon.png] Polymorphisms in GRIK4, HTR2A, and FKBP5 Show Interactive Effects in Predicting Remission to Antidepressant Treatment



[PMID 19758789] HTR2A gene variation is involved in antidepressant treatment response


OMIM182135
Desc
Variant0003
Relatedalso


[PMID 22006095] Serotonin receptor 2A (HTR2A) gene polymorphism predicts treatment response to venlafaxine XR in generalized anxiety disorder


[PMID 18803430OA-icon.png] Pharmacogenetics of major depression: insights from level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial.


[PMID 19077664OA-icon.png] Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.


[PMID 19381154] Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study.


[PMID 19937159] HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort.


[PMID 20047709OA-icon.png] Genetic variation in HTR2A influences serotonin transporter binding potential as measured using PET and [11C]DASB.


[PMID 20194481OA-icon.png] Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder.


[PMID 20453658] 5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder.


[PMID 21136126] Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression.


[PMID 21172166OA-icon.png] Pharmacogenetics of antidepressant response.


[PMID 21741447] Interaction between two HTR2A polymorphisms and gender is associated with treatment response in MDD.


GET Evidence
rs7997012
aa_change
aa_change_short
impact pharmacogenetic
qualified_impact Insufficiently evaluated pharmacogenetic
overall_frequency 0.765625
summary



[PMID 23798967OA-icon.png] No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression


[PMID 22907732] Interaction between polymorphisms in serotonin transporter (SLC6A4) and serotonin receptor 2A (HTR2A) genes predict treatment response to venlafaxine XR in generalized anxiety disorder.


[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.