|(A;A)||~18% more likely to respond to citalopram|
|(G;G)||~18% less likely to respond to citalopram|
From this article [PMID 16642436]:
"HTR2A encodes the serotonin 2A receptor, which is downregulated by citalopram. Participants who were homozygous for the A allele had an 18% reduction in absolute risk of having no response to treatment, compared with those homozygous for the other allele."
- See also Anxiety Blog posting
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[PMID 19590397] 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression
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[PMID 18803430] Pharmacogenetics of major depression: insights from level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial.
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[PMID 19381154] Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study.
[PMID 19937159] HTR2A is associated with SSRI response in major depressive disorder in a Japanese cohort.
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[PMID 21172166] Pharmacogenetics of antidepressant response.
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|qualified_impact||Insufficiently evaluated pharmacogenetic|
[PMID 23798967] No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression
[PMID 22907732] Interaction between polymorphisms in serotonin transporter (SLC6A4) and serotonin receptor 2A (HTR2A) genes predict treatment response to venlafaxine XR in generalized anxiety disorder.
[PMID 23733030] Pharmacogenetics in major depression: a comprehensive meta-analysis.