From SNPedia
rs1859962 is a SNP on chromosome 17q24.3, associated with increased risk for prostate cancer in several studies.
In a study of over 3,600 Caucasians with prostate cancer, rs1859962 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On its own, the rs1859962(G;G) risk genotype yields an odds ratio for developing prostate cancer of 1.28 (CI: 1.11-1.47, p=5.5x10e-4) and may account for 6.5% of population attributable risk.10.1056/NEJMoa075819
news linked to Prostate cancer and type-2 diabetes
cancer-genetics these snps influence genetic risk for prostate cancer
| ? | (G;G) (G;T) (T;T) |
|---|
 |
| GWAS
|
| SNP
| rs1859962
|
| PubMedID
| [PMID 17603485]
|
| Condition
| Prostate cancer
|
| Gene
| Intergenic
|
| Risk Allele
| G
|
| pValue
| 3.00E-010
|
| OR
| 1.2
|
| 95% CI
| 1.14-1.27
|
| GWAS snp
|
| PMID
| [PMID 18264097]
|
| Trait
| Prostate cancer
|
| Title
| Multiple newly identified loci associated with prostate cancer susceptibility
|
| Risk Allele
| G
|
| P-val
| 9.9999999999999995E-7
|
| Odds Ratio
| 1.26 [NR]
|
| PharmGKB | PA162356123 |
| Name | |
| Annotation | The G allele of rs1859962 was found to contribute to the risk of prostate cancer in four populations of European descent. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17603485 |
| Drugs | |
| Diseases | Prostatic Neoplasms |
| Curation Level | Curated |
| GWAS snp
|
| PMID
| [PMID 19767753]
|
| Trait
| Prostate cancer
|
| Title
| Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
|
| Risk Allele
| T
|
| P-val
| 2E-16
|
| Odds Ratio
| NR NR
|
