Rs1800796

From SNPedia

[PMID 17996468] rs1800796 IL-6 572G>C polymorphism (and h.211 haplotype) is associated with Abdominal Aortic Aneurysm (AAA)

[PMID 17508011]] Our results provide evidence that there is a clear genetic influence of IL6 -572C>G polymorphism on plasma levels of fibrinogen and CRP, but this polymorphism does not lead to elevated blood pressure.

[PMID 18257935] rs1800797, rs1800796 and rs1800795 have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal osteoarthritis based on 535 women. the G alleles of two promoter single-nucleotide polymorphisms (SNP) G-597A and G-174C were more common among the subjects with symptomatic DIP OA than among those with no disease (p-values corrected for multiple testing 0.020 and 0.024). Also, the carriage of at least one G allele in these positions increased the risk of disease (p=0.006 and, p=0.008, respectively). Carrying a haplotype with the G allele in all three promoter SNPs increased the risk of symptomatic DIP OA more than four-fold (OR 4.45, p=0.001). Carriage of the G-G diplotype indicated an increased risk of both symmetrical DIP OA (OR 1.52 95% CI 1.01 to 2.28) and symptomatic DIP OA (OR 3.67 95% CI 1.50 to 9.00)

[PMID 18449426] rs1800796 coronary artery disease 190 affected Asian Indian sibling pairs

[PMID 19288024] Genetic variants in interleukin-6 modified risk of obstructive sleep apnea syndrome.

[PMID 19435922] Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer

[PMID 19452524] Tumor markers and rectal cancer: support for an inflammation-related pathway

[PMID 19387461] Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection