Rs1800797

From SNPedia

[PMID 18257935] rs1800797, rs1800796 and rs1800795 have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal osteoarthritis based on 535 women. the G alleles of two promoter single-nucleotide polymorphisms (SNP) G-597A and G-174C were more common among the subjects with symptomatic DIP OA than among those with no disease (p-values corrected for multiple testing 0.020 and 0.024). Also, the carriage of at least one G allele in these positions increased the risk of disease (p=0.006 and, p=0.008, respectively). Carrying a haplotype with the G allele in all three promoter SNPs increased the risk of symptomatic DIP OA more than four-fold (OR 4.45, p=0.001). Carriage of the G-G diplotype indicated an increased risk of both symmetrical DIP OA (OR 1.52 95% CI 1.01 to 2.28) and symptomatic DIP OA (OR 3.67 95% CI 1.50 to 9.00)

[PMID 18449426] rs1800797 coronary artery disease 190 affected Asian Indian sibling pairs

[PMID 19435922] Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer

[PMID 19387461] Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection

[PMID 20175976] A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis