rs1800797
| Orientation | plus |
| Stabilized | plus |
| Make rs1800797(A;A) |
| Make rs1800797(A;G) |
| Make rs1800797(G;G) |
| Reference | GRCh38 38.1/141 |
| Chromosome | 7 |
| Position | 22726602 |
| Gene | IL6, LOC541472 |
| is a | snp |
| is | mentioned by |
| dbSNP | rs1800797 |
| dbSNP (classic) | rs1800797 |
| ClinGen | rs1800797 |
| ebi | rs1800797 |
| HLI | rs1800797 |
| Exac | rs1800797 |
| Gnomad | rs1800797 |
| Varsome | rs1800797 |
| LitVar | rs1800797 |
| Map | rs1800797 |
| PheGenI | rs1800797 |
| Biobank | rs1800797 |
| 1000 genomes | rs1800797 |
| hgdp | rs1800797 |
| ensembl | rs1800797 |
| geneview | rs1800797 |
| scholar | rs1800797 |
| rs1800797 | |
| pharmgkb | rs1800797 |
| gwascentral | rs1800797 |
| openSNP | rs1800797 |
| 23andMe | rs1800797 |
| SNPshot | rs1800797 |
| SNPdbe | rs1800797 |
| MSV3d | rs1800797 |
| GWAS Ctlg | rs1800797 |
| GMAF | 0.1818 |
| Max Magnitude | 0 |
| ? | (A;A) (A;G) (G;G) | 28 |
|---|---|---|
|
| ||
[PMID 18257935
] rs1800797, rs1800796 and rs1800795 have been shown to affect both the transcription and secretion of IL-6, to symptomatic distal interphalangeal osteoarthritis based on 535 women. the G alleles of two promoter single-nucleotide polymorphisms (SNP) G-597A and G-174C were more common among the subjects with symptomatic DIP OA than among those with no disease (p-values corrected for multiple testing 0.020 and 0.024). Also, the carriage of at least one G allele in these positions increased the risk of disease (p=0.006 and, p=0.008, respectively). Carrying a haplotype with the G allele in all three promoter SNPs increased the risk of symptomatic DIP OA more than four-fold (OR 4.45, p=0.001). Carriage of the G-G diplotype indicated an increased risk of both symmetrical DIP OA (OR 1.52 95% CI 1.01 to 2.28) and symptomatic DIP OA (OR 3.67 95% CI 1.50 to 9.00)
[PMID 18449426] rs1800797 coronary artery disease 190 affected Asian Indian sibling pairs
[PMID 19435922] Host genetic variants in the interleukin-6 promoter predict poor outcome in patients with estrogen receptor-positive, node-positive breast cancer
[PMID 19387461] Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection
[PMID 20175976] A meta-analysis of interleukin-6 promoter polymorphisms on risk of hip and knee osteoarthritis
{{PMID Auto |PMID=20080841 |Title=Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components }}
[PMID 21129206] Exploring multilocus associations of inflammation genes and colorectal cancer risk using hapConstructor
[PMID 21917900] Genetic Variations and Interactions in Anti-inflammatory Cytokine Pathway Genes in the Outcome of Leprosy: A Study Conducted on a MassARRAY Platform
[PMID 22107760] Genetic susceptibility of intervertebral disc degeneration among young Finnish adults
[PMID 16449530] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.
[PMID 16644865] Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis.
[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.
[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.
[PMID 17416766] IL6, aspirin, nonsteroidal anti-inflammatory drugs, and breast cancer risk in women living in the southwestern United States.
[PMID 17594514] Active and passive smoking, IL6, ESR1, and breast cancer risk.
[PMID 17623760] Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals.
[PMID 17694420] IL6 genotypes and colon and rectal cancer.
[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.
[PMID 17996468] Polymorphisms of the interleukin-6 gene promoter and abdominal aortic aneurysm.
[PMID 18194558] A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.
[PMID 18239642] Modifying effects of IL-6 polymorphisms on body size-associated breast cancer risk.
[PMID 18276608] Interleukin-6 (IL-6) and receptor (IL6-R) gene haplotypes associate with amniotic fluid protein concentrations in preterm birth.
[PMID 18321738] Is the interleukin-6 haplotype a prognostic factor for sciatica?
[PMID 18420533] The effect of IL6-174C/G polymorphism on postprandial triglyceride metabolism in the GOLDN studyboxs.
[PMID 18496509] An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.
[PMID 18603647] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.
[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.
[PMID 18727828] Ischemic stroke risk, smoking, and the genetics of inflammation in a biracial population: the stroke prevention in young women study.
[PMID 18781131] Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma.
[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.
[PMID 19267250] C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.
[PMID 19272152] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.
[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.
[PMID 19359268] Associations of IL6 polymorphisms with lung function decline and COPD.
[PMID 19505919] Toll-like receptor signaling pathway variants and prostate cancer mortality.
[PMID 19585495] Association of HLA-DRB1, interleukin-6 and cyclin D1 polymorphisms with cervical cancer in the Swedish population--a candidate gene approach.
[PMID 19698145] Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease.
[PMID 20144192] Chromosome 7p linkage and association study for diabetes related traits and type 2 diabetes in an African-American population enriched for nephropathy.
[PMID 23050050] Gender difference in genetic association between IL1A variant and early lumbar disc degeneration: a three-year follow-up
[PMID 22714907] IL6 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review.
[PMID 24059848] Interleukin-6 polymorphisms and hematologic malignancy: a re-appraisal of evidence from genetic association studies
[PMID 24974143] Association of interleukin 6 single nucleotide polymorphisms with allergic rhinitis
[PMID 25030201] Association between Interleukin-6 Gene Polymorphisms and Rheumatoid Arthritis in Chinese Han Population: A Case-Control Study and A Meta-analysis
[PMID 25648033] IL-6 promoter functional polymorphism -572C/G affects spontaneous clearance of hepatitis B virus infection
[PMID 25305747] IL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort
[PMID 25299085] IL-6 gene promoter polymorphisms and risk of coronary artery disease in a Chinese population
[PMID 25422198] Polymorphic variation of inflammation-related genes and risk of non-Hodgkin lymphoma for Uygur and Han Chinese in Xinjiang
[PMID 26198920] Family-based association study of interleukin 6 (IL6) and its receptor (IL6R) functional polymorphisms in schizophrenia in the Polish population
[PMID 26938664] Interleukin 6 SNP rs1800797 associates with the risk of adult-onset asthma.
[PMID 27502736] Identification of IL6 as a susceptibility gene for major depressive disorder.
[PMID 28268030] Influence of IL1B, IL6 and IL10 gene variants and plasma fatty acid interaction on metabolic syndrome risk in a cross-sectional population-based study.
[PMID 28739396] Genetic association of pro-inflammatory cytokine gene polymorphisms with coronary artery disease (CAD) in a North Indian population.
[PMID 31082334] [Correlation between interleukin-6 single nucleotide polymorphism and the occurrence and prognosis of hepatitis B virus-associated acute-on-chronic liver failure].
[PMID 32046104] The Impact of IL-6 and IL-10 Gene Polymorphisms in Diffuse Large B-Cell Lymphoma Risk and Overall Survival in an Arab Population: A Case-Control Study.
[PMID 32391092] Association of angiogenesis and inflammation-related gene functional polymorphisms with early-stage breast cancer prognosis.
