From SNPedia
rs140504, a SNP in the
BCR gene on chromosome 22, has been associated with increased risk for
bipolar disorder. The odds ratio for carriers of the minor allele (G) are reported as 1.45 (CI:1.11 - 1.84, p=0.0054) based on a study of 171 Japanese patients.[
PMID 15866548]
| ? | (A;A) (A;G) (G;G) |
|---|
 |
| Venter snp
|
| Source
| plos
|
| Gene
| BCR
|
| allele
| G
|
| frequency
| 0.125
|
| sift
| TOLERATED
|
| HuRef
| 1103691014305
|
| Disease Association
| A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia (CML) (MIM:608232). Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
|
Related to MAJOR AFFECTIVE DISORDER 1; MAFD1
according to
omim 125480. See
also
