Rs11833579

rs11833579 is one of 2 SNPs found near the NINJ2 gene on chromosome 12 associated with increased risk for both total stroke and ischemic stroke, based on a large study of four cohorts including both blacks and whites. The other (linked) SNP is rs12425791.

Results of this 20,000+ person study suggested that each minor (risk) allele at these two SNPs increases the hazard ratio for total stroke about 1.31 (CI: 1.19 - 1.44) and for ischemic stroke by about 1.40 (CI: 1.27 - 1.56). The corresponding population attributable risks were 11 to 13% for total stroke and 14 to 17% for ischemic stroke, which is fairly high for this sort of SNP. 10.1056/NEJMoa0900094

Note: a meta-analysis totaling over 8,000 patients did not replicate any association between either rs12425791 or rs11833579 and ischemic (or incident) stroke.[1]

[PMID 21722921] NINJ2 polymorphism is associated with ischemic stroke in Chinese Han population

[PMID 21832970] Association between two key SNPs on chromosome 12p13 and ischemic stroke in Chinese Han population

[PMID 22011019] Association of two single nucleotide polymorphisms from genomewide association studies with clinical phenotypes of cerebral ischemia

[PMID 22212150] Association between genetic variant on Chromosome 12p13 and stroke survival and recurrence: A one year prospective study in Taiwan

[PMID 22429733] NINJ2 SNP may affect the onset age of first-ever ischemic stroke without increasing silent cerebrovascular lesions