From SNPedia
[PMID 18477659] rs1470579 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.18 (CI: 1.07-1.31, p = 8.3 x 10e-4)
[PMID 18461161] T2D and normal glucose tolerant (NGT) individuals. (3,295 T2D and 3,595 NGT), strong associations with T2D were found for
- CDKAL1 (OR(rs7756992) = 1.30[1.19-1.42], P = 2.3x10(-9))
- CDKN2A/2B (OR(rs10811661) = 0.74[0.66-0.82], P = 3.5x10(-8))
- IGFBP2 (OR(rs1470579) = 1.17[1.07-1.27], P = 0.0003) SNPs.
T2D risk increased strongly when risk alleles, including the previously discovered T2D-associated TCF7L2 rs7903146 SNP, were combined (8.68-fold for the 14% of French individuals carrying 18 to 30 risk alleles with an allelic OR of 1.24)
[PMID 18430866] Neither rs4402960 or rs1470579 were found to be associated with type-2 diabetes in a study of 3,000 French Caucasians.
[PMID 19033397] This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).
Note: rs1470579 is fairly tightly linked (r2=0.87) with another IGF2BP2 gene SNP also associated with type-2 diabetes, rs4402960
| ? | (A;A) (A;C) (C;C) |
|---|
 |
| GWAS snp
|
| PMID
| [PMID 17463246]
|
| Trait
| Type 2 diabetes
|
| Title
| Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
|
| Risk Allele
| C
|
| P-val
| 1E-9
|
| Odds Ratio
| 1.17 [1.11-1.23]
|
