From SNPedia
| Geno
|
Mag
|
Summary
|
| (G;G)
|
0
|
normal
|
| (G;T)
|
|
1.4x increased risk of atrial fibrillation and ischemic stroke
|
| (T;T)
|
|
1.4x increased risk of atrial fibrillation and ischemic stroke
|
| ? | (G;G) (G;T) (T;T) | 28 |
|---|
 |
Two SNPs from chromosome 4q25,
rs2200733 and
rs10033464, were found to be associated with
atrial fibrillation in a study of both European and Asian populations. The odds ratio associated with one or more copies of either risk allele was ~1.4x.[
PMID 17603472]
[PMID 18991354] In 1,661 Icelandic ischemic stroke samples and two large European replication sets combined, rs10033464 was associated with cardioembolic stroke (CES) (odds ratio 1.27, p = 6.1 x 10e-4).
[PMID 19141561] rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.
| OMIM | 611494 |
| Desc | ATRIAL FIBRILLATION, FAMILIAL, 5; ATFB5 |
| Variant | |
| Related | also |
| PharmGKB | PA162356664 |
| Name | |
| Annotation | GWAS Results: Variants conferring risk of atrial fibrillation on chromosome 4q25 (Initial Sample Size: 550 cases, 4,476 controls; Replication Sample Size: 3,363 cases, 17,616 controls; Risk Allele: rs10033464-T). This variant is associated with atrial fibrillation and atrial flutter. |
| Gene | - |
| Featue | |
| Evidence | PubMed ID:17603472; Web Resource:http://www.genome.gov/gwastudies/ |
| Drugs | |
| Diseases | Atrial Fibrillation, Atrial Flutter |
| Curation Level | Non-Curated |
[PMID 21414601] Usefulness of Single Nucleotide Polymorphism in Chromosome 4q25 to Predict In-Hospital and Long-Term Development of Atrial Fibrillation and Survival in Patients Undergoing Coronary Artery Bypass Grafting
[PMID 21760908] Association between variants on chromosome 4q25, 16q22 and 1q21 and atrial fibrillation in the Polish population
