NOD2
From SNPedia
| is a | gene |
| is | mentioned by |
| wikipedia | NOD2 NOD2 |
| NOD2 NOD2 | |
| gopubmed | NOD2 NOD2 |
| 23andMe | NOD2 NOD2 |
dbSNP 64127
PubMed 64127
SADR 64127
HugeNav NOD2 }&geneID=64127&typeSubmit=GO&check=y&typeOption=gene&which=2&pubOrderType=pubD 64127
HEFalMp NOD2 NOD2
| Chromosome position | Summary | |
|---|---|---|
| Rs17221417 | 4929708249,297,082 | |
| Rs2066843 | 4930269949,302,699 | |
| Rs2066844 | 4930342649,303,426 | |
| Rs2066845 | 4931404049,314,040 | |
| Rs2066847 | 4932127849,321,278 | |
| Rs2076756 | 4931438149,314,381 | |
| Rs5743293 | 4932128149,321,281 |
[PMID 17568627] NOD2 3020insC (either rs2066847 or rs5743293) is the most common and highest risk variant in Crohn's disease.
[PMID 18371140] Carriers of any of several NOD2 variant SNPs do not respond well to treatment of perianal fistulating Crohn's disease by the antibiotics ciprofloxacin or metronidazole, whereas carriers of wild-type NOD2 genes have at least some chance (1 in 3) of responding well.
[PMID 17724347] NOD2/CARD15 SNP variants are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation (HSCT) with unrelated donors as compared with wild-type pairs. NOD2/CARD15 genotyping before transplantation may contribute to prognosis and influence clinical management.
[PMID 18756601] No association was found for NOD2/CARD15 SNPs (R702W, G908R) in Chinese patients with inflammatory bowel disease.
The 23andMe blog [Spittoon] reports that the C allele at rs9302752, a SNP in the NOD2 gene, is associated with greater susceptibility to leprosy in Asians (odds ratio 1.59).
