Migraines

From SNPedia

A susceptibility to migraine headaches may be inherited.

http://en.wikipedia.org/wiki/Migraine

These SNPs have been reported to potentially present increased risk for migraines:

• rs1043994, a SNP in the NOTCH3 gene
• rs1042838, a SNP in the PGR gene, specifically associated with migraine-associated vertigo
• A 19bp insertion/deletion promoter polymorphism in the DBH gene, which appears to lack a rs# [PMID 17095019]

These SNPs may also relate to migraines:

• rs941298
• rs1042713
• rs1042714
• rs1042838
• rs1229984
• rs1799752
• rs1800888
• rs1801133
• rs2653349
• rs2860174
• rs4363087
• rs4795541
• rs6951030
• rs28933398
• rs28933399
• rs28933400
• rs28933401
• rs1229984

Numerous single studies indicate a correlation between a given SNP and migraines, but subsequent studies, whether of different populations, larger patient numbers, or via pooled meta-analyses, have often failed to replicate the initial findings. Caveat emptor!

Drugs used to treat migraines may also be more or less successful based on a patient's genotype, since SNPs in a variety of genes affect the metabolism of these drugs. Some of the classes of drugs that have been used to treat migraines include the following:

• beta blockers such as metoprolol
• antidepressants, in particular, tricyclic antidepressants such as imipramine
• anticonvulsants such as valproic acid
• calcium channel blockers such as diltiazem
• triptans such as sumatriptan; see rs5443