From SNPedia
rs1800888, also known as Ile164, is a SNP in the beta 2 adrenergic receptor
ADRB2 gene. The
rs1800888(T) encodes the much rarer Ile allele.
In a study of 330 patients undergoing percutaneous coronary intervention (PCI), patients carrying a rs1800888(T) allele showed a higher incidence of new acute myocardial infarction (17.5% vs. 4.5%, p = 0.001), new PCI (37.5% vs. 13.1%, p < 0.0001), and cardiac death (10% vs. 3.1%, p = 0.036). Regression analysis identified rs1800888(T) as an independent predictor of cardiac death (odds ratio 3.731, CI: 1.004 - 13.867, p = 0.049) and an overall major adverse cardiac event (odds ratio 4.1, CI: 1.945 - 8.640, p = 0.0001).
A replication study was done on a population of 150 patients with peripheral artery disease. The presence of the rs1800888(T) allele was associated with a higher incidence of acute myocardial infarction (54.5% vs. 25.2%, p = 0.035) or combined events (acute myocardial infarction, PCI, or coronary artery bypass graft) (63.6% vs. 30.9%, p = 0.027).[PMID 18940527]
- related to BETA-2-ADRENORECEPTOR AGONIST, REDUCED RESPONSE TO according to omim 109690.0003
| ? | (T;T) (C;C) (C;T) |
|---|
 |
[PMID 18647184] Association between polymorphisms in the beta2-adrenoceptor gene and migraine in women
| PharmGKB | PA164857066 |
| Name | ADRB2: 164Thr>Ile, Thr164Ile, 491T>C, Ile164 |
| Annotation | Congestive heart failure patients with Ile164 variant were at higher risk for death or heart transplantation in 1 year (event rate 76%) compared to those homozygous for Thr164 while others did not observe this finding. After receiving percutaneous coronary intervention, patients carrying Ile164 variant were 3.7 times more like to have cardiac death and 4.1 times more likely to have a major cardiac adverse event (cardiac death, acute MI, new PCI, CABG, and CHF) than those homozygous for Thr164. |
| Gene | ADRB2 |
| Featue | Exon/NonSyn |
| Evidence | Web Resource:http://www.pharmgkb.org/search/annotatedGene/adrb2/variant.jsp#ImportantVariantInformationforADRB2-164 |
| Drugs | |
| Diseases | Cardiomyopathies, Death, Heart Failure, Myocardial Infarction |
| Curation Level | In-Depth |
