| ||Max Magnitude||Chromosome position||Summary|
|Rs4680||2.5||19,963,748||warrior vs worrier; number of other associations|
Variations in this gene control dopamine levels. This can be used to pick appropriate dosages of ADHD medications .
COMT met158 allele associated with OCD in men [PMID 17264842]
[PMID 18698234] 4 SNPs affecting COMT activity were used to define low and high activity haplotypes. These SNPs are: rs6269, rs4633, rs4818, and rs4680.
The mean levodopa dose increased in correspondence with the haplotype activity (low < medium < high). Doses prescribed for G-C-G-G (high activity) haplotype carriers (mean 604.2+/-261.9 mg) were significantly higher than those for the noncarriers (mean 512.2+/-133.5 mg, p<0.05).