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COMT

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is agene
is mentioned by
Full namecatechol-O-methyltransferase
EntrezGene1312
PheGenI1312
VariationViewer1312
ClinVarCOMT
dbSNP1312
SADR1312
HugeNav1312
wikipediaCOMT
googleCOMT
gopubmedCOMT
EVSCOMT
HEFalMpCOMT
23andMeCOMT
UniProtP21964
EnsemblENSG00000093010
OMIM116790
EVSCOMT
# SNPs26
  Max Magnitude Chromosome position Summary
Rs165599 1.5 19,969,258
Rs165688 0 19,963,748
Rs165722 19,961,490
Rs165774 19,965,038
Rs17849308 19,963,748
Rs2020917 19,941,361
Rs2075507 19,940,569
Rs2097603 19,940,569
Rs2239393 19,962,905
Rs3087869 19,953,984
Rs4633 19,962,712
Rs4646312 19,960,814
Rs4646316 19,964,609
Rs4680 2.5 19,963,748 warrior vs worrier
Rs4818 19,963,684
Rs5993882 19,950,010
Rs6267 0 19,962,740
Rs6269 19,962,429
Rs737865 19,942,598
Rs737866 19,942,586
Rs740602 0 19,962,745
Rs740603 19,957,654
Rs769224 19,964,281
Rs8192488 0 19,963,714
Rs9332377 0 19,968,169
Rs933271 19,943,884

Variations in this gene control dopamine levels. This can be used to pick appropriate dosages of ADHD medications [1].

COMT met158 allele associated with OCD in men [PMID 17264842]

[PMID 18698234] 4 SNPs affecting COMT activity were used to define low and high activity haplotypes. These SNPs are: rs6269, rs4633, rs4818, and rs4680. The mean levodopa dose increased in correspondence with the haplotype activity (low < medium < high). Doses prescribed for G-C-G-G (high activity) haplotype carriers (mean 604.2+/-261.9 mg) were significantly higher than those for the noncarriers (mean 512.2+/-133.5 mg, p<0.05).