COMT
From SNPedia
| is a | gene |
| is | mentioned by |
| wikipedia | COMT |
| COMT | |
| gopubmed | COMT |
| 23andMe | COMT |
dbSNP 1312
PubMed 1312
SADR 1312
HugeNav 1312
HEFalMp COMT
| Chromosome position | Summary | |
|---|---|---|
| Rs165599 | 1833678018,336,780 | |
| Rs2020917 | 1830888318,308,883 | |
| Rs4633 | 1833023418,330,234 | |
| Rs4680 | 1833127018,331,270 | warrior vs worrier |
| Rs4818 | 1833120618,331,206 | |
| Rs6267 | 1833026218,330,262 | |
| Rs6269 | 1832995118,329,951 | |
| Rs737865 | 1831012018,310,120 |
Variations in this gene control dopamine levels. This can be used to pick appropriate dosages of ADHD medications [1].
COMT met158 allele associated with OCD in men [PMID 17264842]
[PMID 18698234] 4 SNPs affecting COMT activity were used to define low and high activity haplotypes. These SNPs are: rs6269, rs4633, rs4818, and rs4680. The mean levodopa dose increased in correspondence with the haplotype activity (low < medium < high). Doses prescribed for G-C-G-G (high activity) haplotype carriers (mean 604.2+/-261.9 mg) were significantly higher than those for the noncarriers (mean 512.2+/-133.5 mg, p<0.05).
