Rs165599
From SNPedia
| is a | snp |
| is | mentioned by |
| dbSNP | rs165599 |
| hapmap | rs165599 |
| hgdp | rs165599 |
| ensembl | rs165599 |
| gopubmed | rs165599 |
| scholar | rs165599 |
| rs165599 | |
| pharmgkb | rs165599 |
| hgvbaseg2p | rs165599 |
| medrefsnp | rs165599 |
| 23andMe | rs165599 |
| SNP Nexus |
| Gene | COMT |
| Chromosome | 22 |
| Orientation | plus |
| Position | 18336780 |
| Genotype | Effect |
|---|---|
| rs165599(A;A)* | ? |
| rs165599(A;G)* | ? |
| rs165599(G;G)* | ? |
| Genotypes | Magnitude | Summary |
|---|---|---|
| Rs165599(G;A) |
anxiety-related personality traits, ADHD, schizophrenia
part of a three marker haplotype rs737865-rs4680-rs165599
epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes
[PMID 17547583] is associated with bipolar disorder and influences prefrontal aspects of verbal memory in bipolar patients and healthy controls.
[PMID 19369177] Association of the 3' Region of COMT with Schizophrenia in Taiwan
[PMID 19077118] Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia
[PMID 19095219] Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder
[PMID 19605537] Effects of Catechol-O-Methyltransferase on Normal Variation in the Cognitive Function of Children
| PharmGKB | PA162168065 |
| Name | |
| Annotation | This variant may predict a favorable outcome for bupropion treatment for smoking cessation |
| Gene | COMT, ARVCF |
| Featue | |
| Evidence | PubMed ID:16876132 |
| Drugs | bupropion |
| Diseases | Tobacco Use Disorder |
| Curation Level | Curated |
