Rs165599
| is a | snp |
| is | mentioned by |
| dbSNP | rs165599 |
| nextbio | rs165599 |
| hapmap | rs165599 |
| 1000 genomes | rs165599 |
| hgdp | rs165599 |
| ensembl | rs165599 |
| gopubmed | rs165599 |
| scholar | rs165599 |
| rs165599 | |
| pharmgkb | rs165599 |
| gwascentral | rs165599 |
| openSNP | rs165599 |
| 23andMe | rs165599 |
| 23andMe all | rs165599 |
| SNP Nexus | |
| SNPshot | rs165599 |
| SNPdbe | rs165599 |
| MSV3d | rs165599 |
| Gene | COMT |
| Chromosome | 22 |
| Orientation | plus |
| Position | 19956781 |
| Reference | GRCh37 37.1/131 |
| Max Magnitude | 1.5 |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 0 | |
| (A;G) | 1 | |
| (G;G) | 1.5 |
part of a three marker haplotype rs737865-rs4680-rs165599
epistasis between SNPs in COMT (rs2097603, Val158Met (rs4680), rs165599) and polymorphisms in other schizophrenia susceptibility genes
[PMID 17547583] is associated with bipolar disorder and influences prefrontal aspects of verbal memory in bipolar patients and healthy controls.
[PMID 19369177] Association of the 3' Region of COMT with Schizophrenia in Taiwan
[PMID 19077118] Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia
[PMID 19095219] Variation in catechol-O-methyltransferase is associated with duloxetine response in a clinical trial for major depressive disorder
[PMID 19605537] Effects of Catechol-O-Methyltransferase on Normal Variation in the Cognitive Function of Children
| PharmGKB | PA164888988 |
| Name | |
| Annotation | In a study of 78 African American and 65 white patients diagnosed with schizophrenia or schizoaffective disorder, this SNP in the COMT gene was found to have significant associations with response to risperidone over 2-12 weeks in both African-American and white patients. |
| Gene | COMT, ARVCF |
| Featue | |
| Evidence | PubMed ID:19451915 |
| Drugs | risperidone |
| Diseases | Schizophrenia |
| Curation Level | Curated |
[PMID 20586531] The catechol-O-methyl-transferase gene in tardive dyskinesia
| PharmGKB | PA162168065 |
| Name | |
| Annotation | This variant may predict a favorable outcome for bupropion treatment for smoking cessation |
| Gene | COMT, ARVCF |
| Featue | |
| Evidence | PubMed ID:16876132 |
| Drugs | bupropion |
| Diseases | Tobacco Use Disorder |
| Curation Level | Curated |
[PMID 21595525] Sensory gating deficit is associated with catechol-O-methyltransferase polymorphisms in bipolar disorder
[PMID 21934638] A COMT gene haplotype associated with methamphetamine abuse
[PMID 21940152] The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study
