From SNPedia
| ? | (C;C) (C;T) (T;T) | 28 |
|---|
 |
part of a three marker haplotype
rs737865-
rs4680-
rs165599
COMT haplotypes at rs737865 and rs165599 may predict a favorable outcome for bupropion treatment for smoking cessation.
We have typed the IVS 1 rs737865 and 3' rs615599 sites and also included a novel IVS 1 indel polymorphism. We report that the schizophrenia-associated haplotype is significantly heterogeneous in populations worldwide. [PMID 15098000]
may affect non-Hodgkin lymphoma, anxiety-related personality traits
Also mentioned in these PMIDs
[PMID 19369177] Association of the 3' Region of COMT with Schizophrenia in Taiwan
[PMID 19290789] Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment
[PMID 19077118] Genetic variants in COMT and neurocognitive impairment in families of patients with schizophrenia
| PharmGKB | PA162168063 |
| Name | |
| Annotation | This promoter variant is associated with breast cancer risk reduction in two of three case control studies. Functional studies showed that it altered nuclear protein binding patterns and was associated with the up-regulation of transcription, possibly resulting in increased COMT activity. |
| Gene | COMT, TXNRD2 |
| Featue | Intron, NA |
| Evidence | PubMed ID:18632656 |
| Drugs | |
| Diseases | Breast Neoplasms |
| Curation Level | Curated |
[PMID 21940152] The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study
