Age related macular degeneration

From SNPedia

Age related macular degeneration is the leading cause of blindness for people over 50.

omim summarizes current research

Many different SNPs can trigger the disease [PMID 11673412], including:

• rs11200638, a SNP in the HTRA1 gene, claimed to have the strongest influence [PMID 17053108]

• rs1061170 and rs800292, two SNPs in the CFH gene that some have claimed account for up to 78% of the population attributable risk [PMID 16849663, PMID 18316707]

• rs2230199, a SNP in the complement component C3 gene 10.1038/ng2131

• SNPs in the ApoE gene also play a role [PMID 16453339]

• rs3775291 can reduce the risk of having dry ARMD

Macular Degeneration

• http://www.zeenews.com/znnew/articles.asp?rep=2&aid=337673&ssid=28&sid=ENV
• http://www.eurekalert.org/pub_releases/2006-08/hms-vi3082906.php
• [PMID 16940309]
• [PMID 16754848]
• [PMID 17053109] with rs#
• [PMID 17167412]

• rs529825
• rs800292
• rs3766404
• rs1061147
• rs1061170
• rs2274700
• rs203674

Hageman [PMID 15870199]

• rs380390
• rs10272438

Klein [PMID 18682806]

• rs2274700
• rs1410996
• rs7535263

Li [PMID 16936733]

• rs1410996
• rs1061170

Maller [PMID 16936732]

• rs380390

Tuo [PMID 16754848]

• rs10272438

Chen [PMID 18048322]

• rs3753394
• rs551397
• rs800292
• rs2274700
• rs1329428
• rs3753396

Ng [PMID 18421087]

• rs1061170

Francis [PMID 18682806]

• rs641153
• rs4151667
• rs2072633

Gold [PMID 16518403]

• rs4151667
• rs641153

Maller [PMID 16936732]

• rs9332739
• rs547154

Gold [PMID 16518403]

• rs9332739
• rs547154

Maller [PMID 16936732]

• rs10490924

Maller [PMID 16936732]

• rs10490924

Francis [PMID 18682806]

• rs10490924

Lin [PMID 19026638]

• rs3793784

Tuo [PMID 16754848]

HTRA1

• rs11200638

Francis [PMID 18682806]

• rs11200638

Lin [PMID 19026638]