| Geno
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Mag
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Summary
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| (A;A)
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increased risk of coronary heart disease; better response to statins
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| (A;G)
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increased risk of coronary heart disease; better response to statins
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| (G;G)
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normal
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rs7439293 is a SNP in the PALLD gene. The risk allele in terms of heart disease is rs7439293(A).
This SNP is one of the 5 used by Celera's genetic risk score (GRS) for coronary heart disease (CHD).
For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.[PMID 18073581]
[PMID 18799872
] Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study.
[PMID 19752551] Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry.
[PMID 21054356] Polymorphism of the palladin gene and cardiovascular outcome in patients with atherosclerosis.
] Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study.
