|(A;A)||0.5||normal risk of MI|
|(A;G)||1||1.75x risk of MI|
|(G;G)||1.75||1.75x risk of MI|
- rs20455, in the KIF6 gene
- rs3900940, in the MYH15 gene
- rs7439293, in the PALLD gene
- rs2298566, in the SNX19 gene
- rs1010, in the VAMP8 gene
For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.[PMID 18073581]
[PMID 19752551] Polymorphisms associated with both noncardioembolic stroke and coronary heart disease: vienna stroke registry
[PMID 22192511] KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly
[PMID 17767904] Genetic and genomic insights into the molecular basis of atherosclerosis.
[PMID 18599554] Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.
[PMID 19374688] No influence of the VAMP8 rs1010 single nucleotide polymorphism on platelet functions in vitro.
[PMID 19943878] VAMP8/endobrevin is overexpressed in hyperreactive human platelets: suggested role for platelet microRNA.
[PMID 22676277] Vascular associated gene variants in patients with preeclampsia: results from the Danish National Birth Cohort
|qualified_impact||Insufficiently evaluated pharmacogenetic|