||If a smoker, higher risk risk for COPD in smokers in a Hispanic population.
rs543749, also known as IVS21_22 or V-1, is a SNP in the ADAM metallopeptidase domain 33 ADAM33 gene.
A study of ~600 non-Hispanic white males who smoked concluded that rs543749(G;G) carriers, i.e. those homozygous for the most common allele, were more likely (p< 0.0026, after Bonferroni correction) to develop chronic obstructive pulmonary disease (COPD) than carriers of one or two rs543749(T) alleles.10.1186/1465-9921-10-21
[PMID 17878941] ADAM33, a new candidate for psoriasis susceptibility.
[PMID 18560587] Replication of association between ADAM33 polymorphisms and psoriasis.
[PMID 19284602] Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers.
[PMID 21320344] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
[PMID 23380143] A disintegrin and metalloprotease 33 (ADAM33) gene polymorphisms and the risk of asthma: a meta-analysis.