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SNPs in the ADAM33 gene have been linked to a predisposition to asthma and bronchial hyperresponsiveness. [PMID 12110844, PMID 14564349]
These SNPs include:
At an individual level, another study [PMID 16773130] has found no association between any individual ADAM33 SNP and asthma predisposition, but they did find an association with ADAM33 haplotypes, leading to the conclusion that either some ADAM33 SNPs or SNPs in another gene located nearby are associated with asthma.
SNPs in the ADAM33 gene have also been linked to increased risk for chronic obstructive pulmonary disease among those who choose to smoke. The most significant of these ADAM33 SNPs are: