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rs17367504

From SNPedia

Orientationplus
Stabilizedplus
Geno Mag Summary
(A;A) 0
(G;G) 1.5 reduction in blood pressure
Make rs17367504(A;G)
ReferenceGRCh38 38.1/141
Chromosome1
Position11802721
GeneMTHFR
is asnp
is mentioned by
dbSNPrs17367504
dbSNP (classic)rs17367504
ClinGenrs17367504
ebirs17367504
HLIrs17367504
Exacrs17367504
Gnomadrs17367504
Varsomers17367504
LitVarrs17367504
Maprs17367504
PheGenIrs17367504
Biobankrs17367504
1000 genomesrs17367504
hgdprs17367504
ensemblrs17367504
geneviewrs17367504
scholarrs17367504
googlers17367504
pharmgkbrs17367504
gwascentralrs17367504
openSNPrs17367504
23andMers17367504
SNPshotrs17367504
SNPdbers17367504
MSV3drs17367504
GWAS Ctlgrs17367504
GMAF0.1097
Max Magnitude1.5
? (A;A) (A;G) (G;G) 28


Each G allele is associated with 0.89 x odds of high blood pressure, according to 23andMe. [PMID 19430483OA-icon.png]

23andMe blog blood pressure

GWAS snp
PMID [PMID 19430483OA-icon.png]
Trait Systolic blood pressure
Title Genome-wide association study identifies eight loci associated with blood pressure
Risk Allele G
P-val 2E-13
Odds Ratio 0.85 [0.63-1.07] mm Hg decrease
GWAS snp
PMID [PMID 21909110OA-icon.png]
Trait
Title Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
Risk Allele G
P-val 2E-16
Odds Ratio 0.5340 [0.40-0.66] mmHg decrease


[PMID 19944404OA-icon.png] Genomic dissection of population substructure of Han Chinese and its implication in association studies.


[PMID 20031578OA-icon.png] Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.


[PMID 20852445] Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.


[PMID 22504314OA-icon.png] Orthostatic hypotension and novel blood pressure-associated gene variants: Genetics of Postural Hemodynamics (GPH) Consortium.


[PMID 22525200] Pharmacogenetic implications for eight common blood pressure-associated single-nucleotide polymorphisms.

High Blood Pressure (Hypertension)


[PMID 22959498] Recapitulation of four hypertension susceptibility genes (CSK, CYP17A1, MTHFR, and FGF5) in East Asians.


[PMID 27755385OA-icon.png] The antihypertensive MTHFR gene polymorphism rs17367504-G is a possible novel protective locus for preeclampsia.


[PMID 28425437] Are genetic polymorphisms in the renin-angiotensin-aldosterone system associated with essential hypertension? Evidence from genome-wide association studies.