Have questions? Visit https://www.reddit.com/r/SNPedia

TCF7L2

From SNPedia
is agene
is mentioned by
Full nametranscription factor 7-like 2 (T-cell specific, HMG-box)
EntrezGene6934
PheGenI6934
VariationViewer6934
ClinVarTCF7L2
GeneCardsTCF7L2
dbSNP6934
DiseasesTCF7L2
SADR6934
HugeNav6934
wikipediaTCF7L2
googleTCF7L2
gopubmedTCF7L2
EVSTCF7L2
HEFalMpTCF7L2
MyGene2TCF7L2
23andMeTCF7L2
UniProtQ9NQB0
EnsemblENSG00000148737
OMIM602228
# SNPs32
 Max MagnitudeChromosome positionSummary
rs107491270113,089,594
rs108854060113,017,965
rs11196172112,967,084
rs111961740112,974,337
rs111961750112,976,855
rs111962050113,047,288
rs111962180113,080,735
rs111962240113,095,638
rs122433260113,029,056
rs122553722.2113,049,143Associated with slight increase in risks for T2D, breast and prostate cancers.
rs125731280112,971,038
rs127724240113,120,792
rs177473240112,992,744
rs2904750113,114,260
rs2904810113,164,066
rs2904870113,149,972
rs2904890113,147,296
rs34872471112,994,312
rs38145701.5112,948,751
rs41326700113,008,012
rs45065652112,996,282
rs65851940112,957,712
rs70744400113,025,665
rs70944630112,952,224
rs74157220113,118,108
rs78953070112,984,202
rs78953400113,041,766
rs79016950112,994,329
rs79031463.5112,998,590Associated with T2D.
rs79045190113,014,168
rs79179830112,973,123
rs79240800113,027,253

These two snps rs12255372 and rs7903146 greatly influence your risk of Type-2 diabetes.

This has been confirmed by

  • several researchers ([PMID 16936217] [PMID 16855264] [1] [PMID 16936217])
  • Research [[2] [PMID 16936217] shows snps in the gene TCF7L2 significantly increases the risk of Type-2 diabetes.
  • Refining the impact of TCF7L2 gene variants on Type-2 diabetes and adaptive evolution [PMID 17206141].
  • [3] Carrying two copies of a common variant of TCF7L2 doubles your chances of developing Type-2 diabetes and puts you in a similar risk category to being clinically obese. A common variant of the gene increased the risk of developing diabetes by 50 per cent. Carrying two copies of the variant gene increased the risk two-fold, to nearly 100 per cent. In the population as a whole, the impact of this gene on the risk of developing diabetes is as big as the problem of being clinically obese (having a body mass index over 30).
  • Polymorphism in TCF7L2 is associated with reduced insulin secretion in nondiabetic women [PMID 17130514]


This news article summarizes how snps increase the risk



IHOP Information Hyperlinked Over Proteins.


PolyDoms Snap


[PMID 17519421] Variation in TCF7L2 influences therapeutic response to sulfonylureas - related to diabetes