TCF7L2
From SNPedia
| is a | gene |
| is | mentioned by |
| Full name | transcription factor 7-like 2 (T-cell specific, HMG-box) |
| EntrezGene | 6934 |
| PheGenI | 6934 |
| VariationViewer | 6934 |
| ClinVar | TCF7L2 |
| GeneCards | TCF7L2 |
| dbSNP | 6934 |
| Diseases | TCF7L2 |
| SADR | 6934 |
| HugeNav | 6934 |
| wikipedia | TCF7L2 |
| TCF7L2 | |
| gopubmed | TCF7L2 |
| EVS | TCF7L2 |
| HEFalMp | TCF7L2 |
| MyGene2 | TCF7L2 |
| 23andMe | TCF7L2 |
| UniProt | Q9NQB0 |
| Ensembl | ENSG00000148737 |
| OMIM | 602228 |
| # SNPs | 32 |
| Max Magnitude | Chromosome position | Summary | |
|---|---|---|---|
| rs10749127 | 0 | 113,089,594 | |
| rs10885406 | 0 | 113,017,965 | |
| rs11196172 | 0 | 112,967,084 | |
| rs11196174 | 0 | 112,974,337 | |
| rs11196175 | 0 | 112,976,855 | |
| rs11196205 | 0 | 113,047,288 | |
| rs11196218 | 0 | 113,080,735 | |
| rs11196224 | 0 | 113,095,638 | |
| rs12243326 | 0 | 113,029,056 | |
| rs12255372 | 2.2 | 113,049,143 | Associated with slight increase in risks for T2D, breast and prostate cancers. |
| rs12573128 | 0 | 112,971,038 | |
| rs12772424 | 0 | 113,120,792 | |
| rs17747324 | 0 | 112,992,744 | |
| rs290475 | 0 | 113,114,260 | |
| rs290481 | 0 | 113,164,066 | |
| rs290487 | 0 | 113,149,972 | |
| rs290489 | 0 | 113,147,296 | |
| rs34872471 | 0 | 112,994,312 | |
| rs3814570 | 1.5 | 112,948,751 | |
| rs4132670 | 0 | 113,008,012 | |
| rs4506565 | 2 | 112,996,282 | |
| rs6585194 | 0 | 112,957,712 | |
| rs7074440 | 0 | 113,025,665 | |
| rs7094463 | 0 | 112,952,224 | |
| rs74157220 | 0 | 113,118,108 | |
| rs7895307 | 0 | 112,984,202 | |
| rs7895340 | 0 | 113,041,766 | |
| rs7901695 | 0 | 112,994,329 | |
| rs7903146 | 3.5 | 112,998,590 | Associated with T2D. |
| rs7904519 | 0 | 113,014,168 | |
| rs7917983 | 0 | 112,973,123 | |
| rs7924080 | 0 | 113,027,253 |
These two snps rs12255372 and rs7903146 greatly influence your risk of Type-2 diabetes.
This has been confirmed by
- several researchers ([PMID 16936217] [PMID 16855264] [1] [PMID 16936217])
- Research [[2] [PMID 16936217] shows snps in the gene TCF7L2 significantly increases the risk of Type-2 diabetes.
- Refining the impact of TCF7L2 gene variants on Type-2 diabetes and adaptive evolution [PMID 17206141].
- [3] Carrying two copies of a common variant of TCF7L2 doubles your chances of developing Type-2 diabetes and puts you in a similar risk category to being clinically obese. A common variant of the gene increased the risk of developing diabetes by 50 per cent. Carrying two copies of the variant gene increased the risk two-fold, to nearly 100 per cent. In the population as a whole, the impact of this gene on the risk of developing diabetes is as big as the problem of being clinically obese (having a body mass index over 30).
- Polymorphism in TCF7L2 is associated with reduced insulin secretion in nondiabetic women [PMID 17130514]
This news article summarizes how snps increase the risk
IHOP Information Hyperlinked Over Proteins.
[PMID 17519421] Variation in TCF7L2 influences therapeutic response to sulfonylureas - related to diabetes
