Sequence Variants in SLC16A11 Are a Common Risk Factor for Type 2 Diabetes in Mexico <http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12828.html>
A haplotype of four SNPs in this gene, common in Native Americans, may have originated in Neanderthals.
- rs117767867 is considered the tag SNP
This haplotype raises the risk by 25% in heterozygotes and 50% in homozygotes for type-2 diabetes, and it may also lead to the development of type-2 diabetes at a younger age and lower BMI. This haplotype is found at ~50% frequency in Native American samples and ~10% in east Asian, but is rare in Europeans and Africans.