|| 1.25x risk for type 2 diabetes
|| 1.5x risk for type 2 diabetes
is a SNP in the SLC16A11
gene on chromosome 17.
This SNP, rs117767867 is considered the tag SNP for a haplotype consisting of 4 missense variants identified as relatively common in the Native American population and having introgressed into modern humans via admixture with Neanderthals. The other 3 missense variants are rs13342692, rs75418188, and rs75493593. This haplotype raises the risk by 25% in heterozygotes and 50% in homozygotes for type-2 diabetes, and it may also lead to the development of type-2 diabetes at a younger age and lower BMI. This haplotype is found at ~50% frequency in Native American samples and ~10% in east Asian, but is rare in Europeans and Africans.10.1038/nature12828