||in childhood acute lymphoblastic leukemia patients, worse response to vincristine
In a study of ~300 patients with childhood acute lymphoblastic leukemia (ALL) treated with vincristine, rs924607(T;T) patients, 28 of 50 (56%) developed at least 1 episode of grade 2 to 4 peripheral neuropathy. This was a significantly higher rate than in patients with (C;C) or (C;T) genotypes (58/271 patients; p = 2.4×10e-6). The severity of neuropathy was also greater in (T;T) patients.[PMID 25710658]
[PMID 27618250] An inherited genetic variant in CEP72 promoter predisposes to vincristine-induced peripheral neuropathy in adults with acute lymphoblastic leukemia.