Important Variant Information for CYP2J2. involved in metabolism of some drugs.
rs890293, also known as -50C>T, is a SNP in the CYP2J2 gene.
A study of 5,740 participants of the cardiovascular cohort of the 'Malmö Diet and Cancer' study was monitored for cardiovascular events over 10 years, with the conclusion being there was no significant association between this SNP and either hypertension or ischemic events.[PMID 19851119]
[PMID 20140850] Genetic Variation in the G-50T Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2 Gene and the Risk of Younger Onset Type 2 Diabetes among Chinese Population: Potential Interaction with Body Mass Index and Family History
[PMID 18769365] Role of cytochrome P450 2C8 and 2J2 genotypes in calcineurin inhibitor-induced chronic kidney disease.
[PMID 23684773] A Novel Polymorphism of the CYP2J2 Gene is Associated with Coronary Artery Disease in Uygur Population in China
[PMID 25796175] CYP2J2 rs890293 polymorphism is associated with susceptibility to Alzheimer's disease in the Chinese Han population
[PMID 27396818] Gene- gene Interaction between CYP2J2 and PPAR -γ gene on Late-Onset Alzheimer's disease in the eastern Chinese Han Population.
[PMID 30518987] A comprehensive study revealed SNP-SNP interactions and a sex-dependent relationship between polymorphisms of the CYP2J2 gene and hypertension risk.