| Geno
|
Mag
|
Summary
|
| (A;A)
|
0
|
|
| (A;G)
|
2
|
0.18x reduced risk of developing progressive supranuclear palsy
|
| (G;G)
|
2.5
|
~0.05x (thus greatly) reduced risk for developing progressive supranuclear palsy
|
| GWAS snp
|
| PMID
|
[PMID 21044948 ]
|
| Trait
|
|
| Title
|
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21
|
| Risk Allele
|
|
| P-val
|
7E-12
|
| Odds Ratio
|
1.3000 [1.19-1.43]
|
Each copy of the G version of rs8070723 was associated with about 5.5 times lower odds of progressive supranuclear palsy. The researchers identified smaller effects at rs1411478, rs7571971 and rs1768208. 23andMe blog
| GWAS snp
|
| PMID
|
[PMID 21685912]
|
| Trait
|
|
| Title
|
Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
|
| Risk Allele
|
|
| P-val
|
2E-118
|
| Odds Ratio
|
5.1100 [4.43-5.91]
|
[PMID 18985386] Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
[PMID 20070850] Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
[PMID 27115769] Gene expression, methylation and neuropathology correlations at progressive supranuclear palsy risk loci.
[PMID 25324900] Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels.
[PMID 28189700] CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN.
]
