rs80359421

plus

Geno	Mag	Summary
(-;CT)	6	BRCA2 variant considered pathogenic for breast cancer
(CT;CT)	0	common in clinvar

Make rs80359421(-;-)

Reference

GRCh38 38.1/141

Chromosome

13

Position

32338392

Gene

BRCA2

is a	snp
is	mentioned by
dbSNP	rs80359421
ClinGen	rs80359421
ebi	rs80359421
HLI	rs80359421
Exac	rs80359421
Varsome	rs80359421
Map	rs80359421
PheGenI	rs80359421
hapmap	rs80359421
1000 genomes	rs80359421
hgdp	rs80359421
ensembl	rs80359421
gopubmed	rs80359421
geneview	rs80359421
scholar	rs80359421
google	rs80359421
pharmgkb	rs80359421
gwascentral	rs80359421
openSNP	rs80359421
23andMe	rs80359421
23andMe all	rs80359421
SNP Nexus
SNPshot	rs80359421
SNPdbe	rs80359421
MSV3d	rs80359421
GWAS Ctlg	rs80359421

Max Magnitude

6

rs80359421, also known as 4265delCT, c.4037_4038delCT and p.Thr1346Serfs, is a variant in the BRCA2 gene considered pathogenic for breast cancer in ClinVar.

Note: the 23andMe probe (i5009150) corresponding to this genotype is unreliable (prone to false results).

ClinVar
Risk	rs80359421(-;-)
Alt	rs80359421(-;-)
Reference	Rs80359421(CT;CT)
Significance	Pathogenic
Disease	Familial cancer of breast Breast-ovarian cancer not provided
Variation	info
Gene	BRCA2
CLNDBN	Familial cancer of breast Breast-ovarian cancer, familial 2 not provided
Reversed	0
HGVS	NC_000013.10:g.32912529_32912530delCT
CLNSRC	Breast Cancer Information Core (BRCA2)
CLNACC	RCV000044334.2, RCV000077318.5, RCV000478122.1,