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From SNPedia

Geno Mag Summary
(A;A) 0 common in clinvar
Make rs743572(A;G)
Make rs743572(G;G)
ReferenceGRCh38 38.1/142
is asnp
is mentioned by
dbSNP (classic)rs743572
1000 genomesrs743572
GWAS Ctlgrs743572
Max Magnitude0

rs743572, known best as the CYP17 -34 T/C or T>C variant, is a variant in the 5' upstream region of the CYP17A1 gene.

? (A;A) (A;G) (G;G) 28

[PMID 19415745] Genetic polymorphisms of estrogen metabolizing enzyme and breast cancer risk in Thai women

[PMID 18682255] Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions

[PMID 20432167] Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians

[PMID 21824047] Genetic polymorphisms associated with steroids metabolism and insulin action in polycystic ovary syndrome

[PMID 22418777OA-icon.png] Estrogen-related genes and their contribution to racial differences in breast cancer risk

[PMID 22658813] Association Between Polymorphisms in COMT, PLCH1, and CYP17A1, and Non-Small-Cell Lung Cancer Risk in Chinese Nonsmokers

[PMID 17307805] CYP17 genotype is associated with short menstrual cycles, early oral contraceptive use and BRCA mutation status in young healthy women.

[PMID 17615053OA-icon.png] Polymorphisms in the cytochrome P450 genes CYP1A2, CYP1B1, CYP3A4, CYP3A5, CYP11A1, CYP17A1, CYP19A1 and colorectal cancer risk.

[PMID 17986287] The rs743572 common variant in the promoter of CYP17A1 is not associated with prostate cancer risk or circulating hormonal levels.

[PMID 18006912] CYP17 genetic variation and risk of breast and prostate cancer from the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3).

[PMID 18163429OA-icon.png] Genetic polymorphisms in CYP17, CYP3A4, CYP19A1, SRD5A2, IGF-1, and IGFBP-3 and prostate cancer risk in African-American men: the Flint Men's Health Study.

[PMID 18172694] Genetic variation in CYP17 and endometrial cancer risk.

[PMID 18437511OA-icon.png] Variants in hormone biosynthesis genes and risk of endometrial cancer.

[PMID 18483327OA-icon.png] Polymorphisms in steroid hormone biosynthesis genes and risk of breast cancer and fibrocystic breast conditions in Chinese women.

[PMID 18601603] Polymorphisms of CYP17A1, CYP19, and androgen in Brazilian women with uterine leiomyomas.

[PMID 18603647OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

[PMID 18628428OA-icon.png] Polymorphisms in genes involved in sex hormone metabolism, estrogen plus progestin hormone therapy use, and risk of postmenopausal breast cancer.

[PMID 18629629] Association of genetic polymorphisms of ER-alpha and the estradiol-synthesizing enzyme genes CYP17 and CYP19 with breast cancer risk in Chinese women.

[PMID 18805939OA-icon.png] Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis.

[PMID 19015200OA-icon.png] Polymorphisms in estrogen- and androgen-metabolizing genes and the risk of gastric cancer.

[PMID 19127255OA-icon.png] Validating genetic risk associations for ovarian cancer through the international Ovarian Cancer Association Consortium.

[PMID 19174490OA-icon.png] Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women.

[PMID 19387820OA-icon.png] Genetic polymorphisms of FSHR, CYP17, CYP1A1, CAPN10, INSR, SERPINE1 genes in adolescent girls with polycystic ovary syndrome.

[PMID 19679043OA-icon.png] African American-preponderant single nucleotide polymorphisms (SNPs) and risk of breast cancer.

[PMID 20171624] Solitary and multiple uterine leiomyomas among Caucasian women: two different disorders?

[PMID 20411041OA-icon.png] Common Variation in the CYP17A1 and IFIT1 Genes on Chromosome 10 Does Not Contribute to the Risk of Endometriosis.

[PMID 20798986] The CYP17A1 -34T > C polymorphism and breast cancer risk in BRCA1 and BRCA2 mutation carriers.

[PMID 21229561] CYP17 gene polymorphisms and prostate cancer risk: A meta-analysis based on 38 independent studies.

[PMID 21644229] [Association of single nucleotide polymorphism in CYP17 and ERalpha genes with endometriosis risk in southern Chinese women].

[PMID 21656827] CYP17 gene polymorphisms and prostate cancer risk: a meta-analysis based on 38 independent studies.

[PMID 23129512OA-icon.png] Polymorphisms in CYP17 and CYP3A4 and prostate cancer in men of African descent

[PMID 24430361] Genetic polymorphisms of ESR1, ESR2, CYP17A1, and CYP19A1 and the risk of breast cancer: a case control study from North India

[PMID 22714708] Genetic polymorphisms of CYP17A1 in steroidogenesis pathway are associated with risk of progression to castration-resistant prostate cancer in Japanese men receiving androgen deprivation therapy.

[PMID 23649771] Genetic variation of the CYP17 and susceptibility to endometrial cancer: a meta-analysis.

[PMID 23809139] Polymorphic variants of CYP17 and CYP19A and risk of infertility in endometriosis.

[PMID 25323563] Quantitative Assessment of the Association Between CYP17 rs743572 Polymorphism and Prostate Cancer Risk

[PMID 26263970OA-icon.png] A Single Nucleotide Polymorphism near the CYP17A1 Gene Is Associated with Left Ventricular Mass in Hypertensive Patients under Pharmacotherapy

[PMID 26276290] Relationship between gene polymorphisms and prostate cancer risk

[PMID 26407154] Evaluation of CYP17A1 and LEP Gene Polymorphisms in Breast Cancer

[PMID 26940238] Association between CYP17A1 rs3824755 and rs743572 gene polymorphisms and Alzheimer's disease in the Chinese Han population.

Risk rs743572(G;G) rs743572(T;T)
Alt rs743572(G;G) rs743572(T;T)
Reference Rs743572(A;A)
Significance Non-pathogenic
Disease Congenital adrenal hyperplasia
Variation info
Gene CYP17A1
CLNDBN Congenital adrenal hyperplasia
Reversed 0
HGVS NC_000010.10:g.104597152A>G
CLNACC RCV000354477.1,