|| normal risk
|| ~normal risk
|| 2.2x higher systemic sclerosis risk
|?|| (C;C) (C;G) (G;G) ||28|
, a common SNP located in the promoter of the CTGF
gene, has been linked to increased risk for systemic sclerosis
(scleroderma) based on a study of 500 Caucasian patients. The odds ratio is 2.2 for (G;G) homozygotes (p<0.001). The reason that the (C) allele appears to be protective is thought to be due to decreased CTGF
|Desc||CONNECTIVE TISSUE GROWTH FACTOR; CTGF|
] Validation of connective tissue growth factor (CTGF/CCN2) and its gene polymorphisms as noninvasive biomarkers for the assessment of liver fibrosis
[PMID 22533709] The CTGF gene -945 G/C polymorphism is not associated with cardiac or kidney complications in subjects with type 2 diabetes
[PMID 19054818] Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population.
[PMID 19822645] Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with schistosomes.
[PMID 22503846] Connective tissue growth factor (CTGF/CCN2): A protagonist in cardiac allograft vasculopathy development?
[PMID 22554650] Wound healing genes and susceptibility to cutaneous leishmaniasis in Brazil
[PMID 24121259] The Influence of CTGF Single-Nucleotide Polymorphisms on Outcomes in Crohn's Disease
[PMID 25030555] Association between Gene Polymorphisms of Connective Tissue Growth Factor and the Progression of Chronic Liver Disease Associated with Hepatitis C
[PMID 25502877] Investigating the association between polymorphisms in connective tissue growth factor and susceptibility to colon carcinoma