rs63751615

plus

Geno	Mag	Summary
(C;C)	0	common in clinvar
(C;T)	5	Lynch syndrome; hereditary nonpolyposis colorectal cancer (HNPCC2)
(T;T)	6	Lynch syndrome; hereditary nonpolyposis colorectal cancer (HNPCC2)

Reference

GRCh38 38.1/141

Chromosome

3

Position

37012098

Gene

MLH1

is a	snp
is	mentioned by
dbSNP	rs63751615
dbSNP (classic)	rs63751615
ClinGen	rs63751615
ebi	rs63751615
HLI	rs63751615
Exac	rs63751615
Gnomad	rs63751615
Varsome	rs63751615
LitVar	rs63751615
Map	rs63751615
PheGenI	rs63751615
Biobank	rs63751615
1000 genomes	rs63751615
hgdp	rs63751615
ensembl	rs63751615
geneview	rs63751615
scholar	rs63751615
google	rs63751615
pharmgkb	rs63751615
gwascentral	rs63751615
openSNP	rs63751615
23andMe	rs63751615
SNPshot	rs63751615
SNPdbe	rs63751615
MSV3d	rs63751615
GWAS Ctlg	rs63751615

Merged from

Rs121912958

Max Magnitude

6

rs63751615 is a SNP in the MLH1 gene on chromosome 3, associated with Lynch syndrome (HNPCC).[PMID 9927033]

This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.[PMID 23788249 ]

See also OMIM 120436.0010

ClinVar
Risk	Rs63751615(T;T)
Alt	Rs63751615(T;T)
Reference	Rs63751615(C;C)
Significance	Pathogenic
Disease	Lynch syndrome II Turcot syndrome Lynch syndrome Hereditary cancer-predisposing syndrome not provided
Variation	info
Gene	MLH1
CLNDBN	Lynch syndrome II Turcot syndrome Lynch syndrome Hereditary cancer-predisposing syndrome not provided
Reversed	0
HGVS	NC_000003.11:g.37053589C>T
CLNSRC	OMIM Allelic Variant
CLNACC	RCV000018616.28, RCV000018617.28, RCV000075801.2, RCV000115485.5, RCV000202205.2,