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From SNPedia

Geno Mag Summary
(C;C) 0 common in clinvar
Make rs4818(G;G)
ReferenceGRCh38 38.1/141
GeneCOMT, MIR4761
is asnp
is mentioned by
dbSNP (classic)rs4818
1000 genomesrs4818
GWAS Ctlgrs4818
Max Magnitude0

Seems to play a role in the brain

This is a synonymous change. it does not affect the amino acid.

[PMID 19367610] Gender-specific COMT Val158Met polymorphism association in Spanish schizophrenic patients

[PMID 19290789] Association studies of catechol-O-methyltransferase (COMT) gene with schizophrenia and response to antipsychotic treatment

[PMID 19551860] Common germline polymorphisms in COMT, CYP19A1, ESR1, PGR, SULT1E1 and STS and survival after a diagnosis of breast cancer


[PMID 19605537OA-icon.png] Effects of Catechol-O-Methyltransferase on Normal Variation in the Cognitive Function of Children

[PMID 19699472] Tolcapone Effects on Gating, Working Memory, and Mood Interact with the Synonymous Catechol-O-methyltransferase rs4818C/G Polymorphism

[PMID 20570835] No evidence for a role of the catechol-O-methyltransferase pain sensitivity haplotypes in chronic widespread pain

[PMID 21120493] Influence of catechol-O-methyltransferase (COMT) gene polymorphisms in pain sensibility of Brazilian fibromialgia patients

[PMID 21300128] COMT Val158met variant and functional haplotypes associated with childhood ADHD history in women with bulimia nervosa

[PMID 21940152] The impact of COMT gene polymorphisms on suicidality in treatment resistant major depressive disorder - A European Multicenter Study

[PMID 22451510] Catechol-O-Methyltransferase Gene and Executive Function in Children With ADHD

[PMID 22528689] Pain sensitivity in fibromyalgia is associated with catechol-O-methyltransferase (COMT) gene

[PMID 10709220OA-icon.png] Through the Looking Glass: Differential Noradenergic Modulation of Prefrontal Cortical Function

[PMID 22178088OA-icon.png] Catechol-O-methyltransferase (COMT) single nucleotide polymorphisms and haplotypes are not major risk factors for polycystic ovary syndrome

[PMID 15290009] Differential expression of human COMT alleles in brain and lymphoblasts detected by RT-coupled 5' nuclease assay.

[PMID 16026601OA-icon.png] Decision forest analysis of 61 single nucleotide polymorphisms in a case-control study of esophageal cancer; a novel method.

[PMID 16816940] Direct molecular haplotyping of multiple polymorphisms within exon 4 of the human catechol-O-methyltransferase gene by liquid chromatography-electrospray ionization time-of-flight mass spectrometry.

[PMID 16848906OA-icon.png] Genetic polymorphisms in monoamine neurotransmitter systems show only weak association with acute post-surgical pain in humans.

[PMID 17135598] No evidence for a major role of polymorphisms during bupropion treatment.

[PMID 17961261OA-icon.png] Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia.

[PMID 17994190] Norepinephrine transporter and catecholamine-O-methyltransferase gene variants and attention-deficit/hyperactivity disorder symptoms in adults.

[PMID 18037454] Planning, decision-making and the COMT rs4818 polymorphism in healthy males.

[PMID 18324659] COMT polymorphisms affecting protein expression are risk factors for endometrial cancer.

[PMID 18574484OA-icon.png] The complex global pattern of genetic variation and linkage disequilibrium at catechol-O-methyltransferase.

[PMID 18698234] The association of functional catechol-O-methyltransferase haplotypes with risk of Parkinson's disease, levodopa treatment response, and complications.

[PMID 18802928] Association between catechol O-methyltransferase (COMT) haplotypes and severity of hyperactivity symptoms in adults.

[PMID 19094200OA-icon.png] Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain.

[PMID 19168589OA-icon.png] Variants in hormone-related genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 19365560OA-icon.png] Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.

[PMID 19693267OA-icon.png] Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.

[PMID 20531207] The impact of catechol-O-methyltransferase SNPs and haplotypes on treatment response phenotypes in major depressive disorder: a case-control association study.

[PMID 20627703] The association of single nucleotide polymorphisms in the catechol-O-methyltransferase gene and pain scores in female patients with major depressive disorder.

[PMID 20842020] Catecholamine-o-methyltransferase polymorphisms are associated with postoperative pain intensity.

[PMID 20863768] Association of catechol-O-methyltransferase genetic variants with outcome in patients undergoing surgical treatment for lumbar degenerative disc disease.

[PMID 21304959OA-icon.png] Epistasis between COMT and MTHFR in maternal-fetal dyads increases risk for preeclampsia.

[PMID 21423693OA-icon.png] Effect sizes in experimental pain produced by gender, genetic variants and sensitization procedures.

[PMID 21462137] [An association study of COMT gene polymorphisms with schizophrenia].

[PMID 21680027] Influence and interaction of genetic polymorphisms in catecholamine neurotransmitter systems and early life stress on antidepressant drug response.

[PMID 22354729OA-icon.png] Association of catechol-O-methyltransferase gene polymorphisms with schizophrenia and negative symptoms in a Chinese population.

[PMID 23872233] The relationship between the presence of ADHD and certain candidate gene polymorphisms in a Turkish sample

[PMID 24448899] Metabolic syndrome in patients taking clozapine: prevalence and influence of catechol-O-methyltransferase genotype

[PMID 22718527OA-icon.png] The associations between OPRM 1 and COMT genotypes and postoperative pain, opioid use, and opioid-induced sedation.

[PMID 22890010] Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.

[PMID 23178897OA-icon.png] The catechol-O-methyltransferase gene (COMT) and cognitive function from childhood through adolescence.

[PMID 24593143OA-icon.png] Genetic polymorphisms of catechol-O-methyltransferase modify the neurobehavioral effects of mercury in children

[PMID 25636089] [Polymorphisms of catechol-O-methyltransferase and monoamine oxidase B genes among Chinese patients with Parkinson's disease]

[PMID 26849490] Association between catechol-O-methyl transferase gene polymorphisms and fibromyalgia in a Korean population: A case-control study.

[PMID 27228319] A Tetra-Primer Amplification Refractory System Technique for the Cost-Effective and Novel Genotyping of Eight Single-Nucleotide Polymorphisms of the Catechol-O-Methyltransferase Gene.

Risk rs4818(G;G) rs4818(T;T)
Alt rs4818(G;G) rs4818(T;T)
Reference Rs4818(C;C)
Significance Non-pathogenic
Disease not specified
Variation info
Gene COMT MIR4761
CLNDBN not specified
Reversed 0
HGVS NC_000022.10:g.19951207C>G
CLNACC RCV000252295.1,

[PMID 28451382OA-icon.png] Roles of functional catechol-O-methyltransferase genotypes in Chinese patients with Parkinson's disease.

[PMID 29559808OA-icon.png] Association of genetic variation in COMT gene with pain related to sickle cell disease in patients from the walk-PHaSST study.