rs4680(A;G)
From SNPedia
| Intermediate dopamine levels, other effects |
| Is a | genotype |
| of | rs4680 |
| Gene | COMT, MIR4761 |
| Chromosome | 22 |
| Position | 19,963,748 |
| Merged from | Rs165688, Rs17849308 |
| mentioned | by |
| Geno | Mag | Summary |
|---|---|---|
| (A;A) | 2.5 | (worrier) advantage in memory and attention tasks |
| (A;G) | Intermediate dopamine levels, other effects | |
| (G;G) | 2.5 | (warrior) multiple associations, see details |
As is often the case with heterozygotes, shares many traits intermediately between the (A;A) and (G;G) homozygotes.
Specific (A;G) findings include:
[PMID 19474754] "The AG genotype of catechol-O-methyltransferase rs4680 [was] significantly associated with bodyweight gain during antidepressive treatment, when adjusted for age and sex."
[PMID 20488458] A potential for a small protective effect against schizophrenia due to moderate dopamine levels compared to the homozygous (A;A) and (G;G), which have much higher and much lower dopaminergic signaling respectively, both of which have been associated with a higher propensity for schizophrenia.
