|Intermediate dopamine levels, other effects|
|Merged from||Rs165688, Rs17849308|
|(A;A)||2.5||(worrier) advantage in memory and attention tasks|
|(A;G)||Intermediate dopamine levels, other effects|
|(G;G)||2.5||(warrior) multiple associations, see details|
As is often the case with heterozygotes, shares many traits intermediately between the (A;A) and (G;G) homozygotes.
Specific (A;G) findings include:
[PMID 19474754] "The AG genotype of catechol-O-methyltransferase rs4680 [was] significantly associated with bodyweight gain during antidepressive treatment, when adjusted for age and sex."
[PMID 20488458] A potential for a small protective effect against schizophrenia due to moderate dopamine levels compared to the homozygous (A;A) and (G;G), which have much higher and much lower dopaminergic signaling respectively, both of which have been associated with a higher propensity for schizophrenia.