||For type-1 diabetics, 1.3x increased nephropathy risk
||For type-1 diabetics, 1.6x increased nephropathy risk
rs4496877 is a SNP near the NOS3 gene.
Several Type-1 diabetes patients pools, totaling over 2,000 patients, plus a meta-analysis were involved in a study concluding that in such patients, the rs4496877 was associated with higher risk for nephropathy. The odds ratio associated with rs4496877(T) was 1.26 (p = 0.002, CI: 1.08-1.47).[PMID 20962522]
A proxy for this SNP (pairwise linkage of 0.96) is rs1800783.
[PMID 19505917] Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors.