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From SNPedia

Geno Mag Summary
(C;C) 0.29x lower risk for periodontitis
(C;T) 0.29x lower risk for periodontitis
(T;T) 0 normal
ReferenceGRCh38 38.1/141
is asnp
is mentioned by
dbSNP (classic)rs419598
1000 genomesrs419598
23andMe allrs419598
GWAS Ctlgrs419598
Max Magnitude0
? (C;C) (C;T) (T;T) 28

May modulate other variations. Also known as the +2018T/C SNP.

In a study of 113 Japanese patients with chronic periodontitis (CP), individuals with the rs419598(C) allele are at 0.29x lower CP risk (p = 0.016).[PMID 18321309]

IL1B -511 allele heterozygotes have a 4 fold higher chance of surviving bacterial meningitis than (either) homozygote [PMID 11023482]. SO what's this have to do with rs419598? Odds of surviving meningitis apparently further increase 2X for IL1B -511 heterozygotes who are also rs419598(T;T), i.e. homozygous for IL1RN +2018 rs419598 (T) allele (the most common one; also known as "+8006").

[PMID 19733643] Interleukin-1 region meta-analysis with osteoarthritis phenotypes

[PMID 19290009] Variants of the interleukin-1 receptor antagonist gene are associated with fat mass in men

[PMID 20709104] Interleukin 1 receptor antagonist polymorphisms are associated with the risk of developing acute coronary syndrome in Mexicans

[PMID 19934104OA-icon.png] Radiographic severity of knee osteoarthritis is conditional on Interleukin 1 Receptor Antagonist gene variations

[PMID 22322675OA-icon.png] IL1RN genetic variations and risk of IPF: a meta-analysis and mRNA expression study.

[PMID 16820586OA-icon.png] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16842617OA-icon.png] Interleukin gene polymorphisms and breast cancer: a case control study and systematic literature review.

[PMID 17176440] The different expression patterns of interleukin-1 receptor antagonist in systemic lupus erythematosus.

[PMID 17665434OA-icon.png] Association of interleukin-6 and interleukin-10 genotypes with radiographic damage in rheumatoid arthritis is dependent on autoantibody status.

[PMID 17705862OA-icon.png] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 18063673] Prospective meta-analysis of interleukin 1 gene complex polymorphisms confirms associations with ankylosing spondylitis.

[PMID 18615156OA-icon.png] Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis.

[PMID 19043479OA-icon.png] Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.

[PMID 19356949OA-icon.png] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 20463618OA-icon.png] Role of polymorphic variants as genetic modulators of infection in neonatal sepsis.

[PMID 20975573] Interleukin 1 beta (IL-1B) and IL-1 antagonist receptor (IL-1RN) gene polymorphisms are associated with the genetic susceptibility and steroid dependence in patients with ulcerative colitis.

[PMID 21146623] Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis.

[PMID 21279638] Coding single-nucleotide polymorphisms of interleukin-1 gene cluster are not associated with Kawasaki disease in the Korean population.

[PMID 22035161] Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations.

[PMID 23192617] IL-1RN +2018T>C polymorphism is correlated with colorectal cancer

[PMID 23212299] Interleukin 1 receptor antagonist (IL1RN) genetic variations condition post-orthodontic external root resorption in endodontically-treated teeth

[PMID 23765978] Association between IL-1RN gene polymorphisms and susceptibility to ankylosing spondylitis: a large Human Genome Epidemiology review and meta-analysis

[PMID 23602982OA-icon.png] IL-1 receptor antagonist gene as a predictive biomarker of progression of knee osteoarthritis in a population cohort

[PMID 22925444] Genetic and immunological markers predict titanium implant failure: a retrospective study.

[PMID 23459936OA-icon.png] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.

[PMID 24008079OA-icon.png] Cytokine gene polymorphisms and progression-free survival in classical Hodgkin lymphoma by EBV status: results from two independent cohorts

[PMID 25865535OA-icon.png] Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia

[PMID 25398456] IL1B and DEFB1 Polymorphisms Increase Susceptibility to Invasive Mold Infection After Solid-Organ Transplantation

[PMID 26391153] Polymorphisms in host immune response associated genes and risk of nasopharyngeal carcinoma development in Portugal

[PMID 27476361] Genetic and clinical risk factors of root resorption associated with orthodontic treatment.

Risk Rs419598(C;C)
Alt Rs419598(C;C)
Reference Rs419598(T;T)
Significance Non-pathogenic
Disease Interleukin 1 receptor antagonist deficiency not specified
Variation info
Gene IL1RN
CLNDBN Interleukin 1 receptor antagonist deficiency not specified
Reversed 0
HGVS NC_000002.11:g.113887207T>C
CLNACC RCV000389038.1, RCV000455594.1,

[PMID 29023524OA-icon.png] Polymorphism IL-1RN rs419598 reduces the susceptibility to generalized periodontitis in a population of European descent.